HCSGD entry for SERP1
1. General information
| Official gene symbol | SERP1 |
|---|---|
| Entrez ID | 27230 |
| Gene full name | stress-associated endoplasmic reticulum protein 1 |
| Other gene symbols | RAMP4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | IEA | biological_process |
| GO:0005783 | Endoplasmic reticulum | IEA TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005840 | Ribosome | TAS | cellular_component |
| GO:0005881 | Cytoplasmic microtubule | IDA | cellular_component |
| GO:0006006 | Glucose metabolic process | IEA | biological_process |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006486 | Protein glycosylation | IEA | biological_process |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007009 | Plasma membrane organization | TAS | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0010259 | Multicellular organismal aging | IEA | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0032024 | Positive regulation of insulin secretion | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045727 | Positive regulation of translation | IEA | biological_process |
| GO:0046622 | Positive regulation of organ growth | IEA | biological_process |
| GO:0048644 | Muscle organ morphogenesis | IEA | biological_process |
| GO:0060124 | Positive regulation of growth hormone secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7435916834 | 0.4506568329 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3429149766 |
| GSE13712_SHEAR | Down | -0.0623064079 |
| GSE13712_STATIC | Down | -0.1804231632 |
| GSE19018 | Down | -0.0617412186 |
| GSE19899_A1 | Up | 0.0923240021 |
| GSE19899_A2 | Up | 0.1977598028 |
| PubMed_21979375_A1 | Up | 0.3620682697 |
| PubMed_21979375_A2 | Up | 0.0156035840 |
| GSE35957 | Up | 0.1264803820 |
| GSE36640 | Up | 0.0602735200 |
| GSE54402 | Up | 0.1935754744 |
| GSE9593 | Down | -0.1036934408 |
| GSE43922 | Down | -0.0042324147 |
| GSE24585 | Down | -0.2489957421 |
| GSE37065 | Down | -0.1498198390 |
| GSE28863_A1 | Down | -0.1842515618 |
| GSE28863_A2 | Up | 0.2316836485 |
| GSE28863_A3 | Down | -0.4711064540 |
| GSE28863_A4 | Down | -0.2134897243 |
| GSE48662 | Up | 0.0194076651 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002684 | Microarray//qRT-PCR | Functional MTI (Weak) | 16549876 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002684 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002684 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT002806 | Luciferase reporter assay//Microarray | Functional MTI (WeaK) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002806 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT004944 | qRT-PCR | Functional MTI (Weak) | 17942906 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005843 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 21282569 |
| hsa-miR-375 | MIMAT0000728 | MIRT019926 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025860 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037576 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044942 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
