HCSGD entry for GPC3

1. General information

Official gene symbolGPC3
Entrez ID2719
Gene full nameglypican 3
Other gene symbolsDGSX GTR2-2 MXR7 OCI-5 SDYS SGB SGBS SGBS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006024Glycosaminoglycan biosynthetic processTASbiological_process
GO:0006027Glycosaminoglycan catabolic processTASbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0009948Anterior/posterior axis specificationIEAbiological_process
GO:0010171Body morphogenesisIEAbiological_process
GO:0030203Glycosaminoglycan metabolic processTASbiological_process
GO:0030204Chondroitin sulfate metabolic processTASbiological_process
GO:0030282Bone mineralizationIEAbiological_process
GO:0030316Osteoclast differentiationIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0031225Anchored component of membraneIEAcellular_component
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0043395Heparan sulfate proteoglycan bindingIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045732Positive regulation of protein catabolic processIEAbiological_process
GO:0045807Positive regulation of endocytosisIEAbiological_process
GO:0045879Negative regulation of smoothened signaling pathwayIEAbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayIEAbiological_process
GO:0045926Negative regulation of growthIEAbiological_process
GO:0046326Positive regulation of glucose importIEAbiological_process
GO:0046658Anchored component of plasma membraneIEAcellular_component
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0060422Peptidyl-dipeptidase inhibitor activityIDAmolecular_function
GO:0060976Coronary vasculature developmentIEAbiological_process
GO:0072138Mesenchymal cell proliferation involved in ureteric bud developmentISSbiological_process
GO:0072180Mesonephric duct morphogenesisIEAbiological_process
GO:0072203Cell proliferation involved in metanephros developmentIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:2000096Positive regulation of Wnt signaling pathway, planar cell polarity pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59735834120.86922027280.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0026390868
GSE13712_SHEARUp0.1394959019
GSE13712_STATICUp0.0849324059
GSE19018Down-0.0804028292
GSE19899_A1Up0.1225877755
GSE19899_A2Up0.1810854464
PubMed_21979375_A1Up0.0275357130
PubMed_21979375_A2Down-0.0021080674
GSE35957Up0.1726983883
GSE36640Down-0.1151151304
GSE54402Up0.0084321315
GSE9593Up0.0377076623
GSE43922Up0.0124600052
GSE24585Down-0.3580840973
GSE37065Up0.0663014334
GSE28863_A1Down-0.0401253319
GSE28863_A2Up0.0365469051
GSE28863_A3Up0.2128358792
GSE28863_A4Up0.0928441794
GSE48662Up0.2414786447

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-219a-5pMIMAT0000276MIRT006231Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22449976
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.