HCSGD entry for GLA
1. General information
| Official gene symbol | GLA |
|---|---|
| Entrez ID | 2717 |
| Gene full name | galactosidase, alpha |
| Other gene symbols | GALA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IDA | molecular_function |
| GO:0004557 | Alpha-galactosidase activity | IDA IMP TAS | molecular_function |
| GO:0005102 | Receptor binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IDA IMP | cellular_component |
| GO:0005737 | Cytoplasm | IMP | cellular_component |
| GO:0005764 | Lysosome | IMP TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IMP | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0009311 | Oligosaccharide metabolic process | IDA | biological_process |
| GO:0016139 | Glycoside catabolic process | IBA | biological_process |
| GO:0016787 | Hydrolase activity | TAS | molecular_function |
| GO:0016936 | Galactoside binding | IEA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045019 | Negative regulation of nitric oxide biosynthetic process | ISS | biological_process |
| GO:0046477 | Glycosylceramide catabolic process | IBA ISS | biological_process |
| GO:0046479 | Glycosphingolipid catabolic process | TAS | biological_process |
| GO:0051001 | Negative regulation of nitric-oxide synthase activity | ISS | biological_process |
| GO:0052692 | Raffinose alpha-galactosidase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0012499221 | 0.7311964363 | 0.0951456647 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.0748797447 |
| GSE13712_SHEAR | Down | -0.1476107032 |
| GSE13712_STATIC | Down | -0.1152904593 |
| GSE19018 | Up | 0.2915405553 |
| GSE19899_A1 | Up | 1.6963953866 |
| GSE19899_A2 | Up | 1.1520503625 |
| PubMed_21979375_A1 | Up | 1.6374443960 |
| PubMed_21979375_A2 | Up | 1.3384317602 |
| GSE35957 | Down | -0.5623753973 |
| GSE36640 | Up | 1.1765052253 |
| GSE54402 | Up | 1.2088480313 |
| GSE9593 | Up | 0.7196933385 |
| GSE43922 | Up | 1.1571080214 |
| GSE24585 | Down | -0.7394005886 |
| GSE37065 | Up | 0.5046908691 |
| GSE28863_A1 | Down | -0.4489618571 |
| GSE28863_A2 | Up | 0.2795294444 |
| GSE28863_A3 | Down | -0.4848628670 |
| GSE28863_A4 | Up | 0.1096283146 |
| GSE48662 | Down | -0.0674627706 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Migalastat | DB05018 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-769-5p | MIMAT0003886 | MIRT039206 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039851 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16706651 | Among the most prevalent of these conditions are Gaucher disease and Fabry disease, which are caused by reduced activity of the housekeeping enzymes glucocerebrosidase and alpha-galactosidase A, respectively |
| 11855860 | Four lysosomal enzyme activities were measured: beta-galactosidase, alpha-galactosidase A, beta-glucoronidase, and acid phosphatase |
| 11855860 | TNF-alpha was the only agent that induced lysosomal activity in senescent fibroblasts, of which only alpha-galactosidase A activity was induced |
| 8755577 | Correction in trans for Fabry disease: expression, secretion and uptake of alpha-galactosidase A in patient-derived cells driven by a high-titer recombinant retroviral vector |
| 8755577 | Fabry disease is an X-linked metabolic disorder due to a deficiency of alpha-galactosidase A (alpha-gal A; EC 3 |
| 8755577 | Virus-producer cells also demonstrate expression of large amounts of both intracellular and secreted alpha-gal A |
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