HCSGD entry for DKK2
1. General information
| Official gene symbol | DKK2 |
|---|---|
| Entrez ID | 27123 |
| Gene full name | dickkopf WNT signaling pathway inhibitor 2 |
| Other gene symbols | DKK-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IEA | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IDA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0021288895 | 0.9809286463 | 0.1235251101 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0395382035 |
| GSE13712_SHEAR | Down | -0.4336902861 |
| GSE13712_STATIC | Down | -0.0105654104 |
| GSE19018 | Up | 0.3021579931 |
| GSE19899_A1 | Up | 0.6994042629 |
| GSE19899_A2 | Up | 1.5889560675 |
| PubMed_21979375_A1 | Up | 0.9528996550 |
| PubMed_21979375_A2 | Up | 2.4890701078 |
| GSE35957 | Down | -0.1319341854 |
| GSE36640 | Up | 2.1790310400 |
| GSE54402 | Up | 0.3038230942 |
| GSE9593 | Up | 0.0470731618 |
| GSE43922 | Up | 0.8543483615 |
| GSE24585 | Up | 0.0613083731 |
| GSE37065 | Down | -0.0845007587 |
| GSE28863_A1 | Down | -0.0770809948 |
| GSE28863_A2 | Up | 0.9348991436 |
| GSE28863_A3 | Up | 0.5190429964 |
| GSE28863_A4 | Up | 0.0568366975 |
| GSE48662 | Up | 0.3039544514 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT003362 | Reporter assay;Microarray | Functional MTI | 20018759 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT007048 | Luciferase reporter assay | Functional MTI | 23060446 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018639 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24478790 | From the genome wide association analysis in 4,289 LLFS participants, we identified a novel intergenic SNP rs7680468 located near PAPSS1 and DKK2 on 4q25 (p = 4 |
| 24286133 | Moreover, transfection with DKK-3, DKK-4, or SOST, which are inhibitors of Wnt signaling, blocked Wnt signaling-mediated TNF-alpha activation; these effects were not observed for DKK-1 or DKK-2 |
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