HCSGD entry for DKK3
1. General information
| Official gene symbol | DKK3 |
|---|---|
| Entrez ID | 27122 |
| Gene full name | dickkopf WNT signaling pathway inhibitor 3 |
| Other gene symbols | REIC RIG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IEA | biological_process |
| GO:0030325 | Adrenal gland development | IEP | biological_process |
| GO:0032348 | Negative regulation of aldosterone biosynthetic process | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IDA | biological_process |
| GO:2000065 | Negative regulation of cortisol biosynthetic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1248795221 | 0.0140884313 | 0.7214560799 | 0.2336706767 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0502552093 |
| GSE13712_SHEAR | Up | 0.4885885703 |
| GSE13712_STATIC | Up | 0.4783450891 |
| GSE19018 | Up | 1.2558953892 |
| GSE19899_A1 | Down | -0.4368935678 |
| GSE19899_A2 | Down | -0.5283797808 |
| PubMed_21979375_A1 | Down | -2.2888703565 |
| PubMed_21979375_A2 | Down | -0.8616092359 |
| GSE35957 | Down | -0.2658613690 |
| GSE36640 | Up | 0.6205946889 |
| GSE54402 | Down | -0.9336906258 |
| GSE9593 | Up | 1.1114790015 |
| GSE43922 | Down | -0.6229907718 |
| GSE24585 | Up | 0.2209347119 |
| GSE37065 | Up | 0.1149050124 |
| GSE28863_A1 | Down | -0.5815087275 |
| GSE28863_A2 | Up | 0.0030891529 |
| GSE28863_A3 | Down | -0.7991238737 |
| GSE28863_A4 | Down | -0.1576205422 |
| GSE48662 | Up | 0.6818435469 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24286133 | Moreover, transfection with DKK-3, DKK-4, or SOST, which are inhibitors of Wnt signaling, blocked Wnt signaling-mediated TNF-alpha activation; these effects were not observed for DKK-1 or DKK-2 |
| 18573329 | Increase of Dkk-3 blood plasma levels in the elderly |
| 18573329 | Gene expression of the secreted glycoprotein Dkk-3 is upregulated during cellular senescence in prostate basal epithelial cells and altered in age-related disorders of the human prostate |
| 18573329 | In order to quantify the influence of such age- and disease-related changes of Dkk-3 levels in body fluids, we established a highly specific and sensitive indirect IEMA |
| 18573329 | Results revealed a significant increase of Dkk-3 blood plasma levels in the elderly (1 |
| 14580871 | TGF-beta-treated prostate epithelial cells neither showed terminal growth arrest nor induction of important senescence-relevant genes, such as p16(INK4A), IFI-6-16, IGFBP-3 or Dkk-3 |
| 10652205 | A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines |
| 10652205 | One of them, which was named REIC, was expressed to a lower degree in three human immortalized cell lines as compared with their parental normal counterparts |
| 10652205 | In addition, the expression of REIC was markedly lower in eight human tumor-derived cell lines (Hep3B and HuH-7 hepatocellular carcinomas, HuH-6 Clone 5 hepatoblastoma, HuCCT-1 cholangiocarcinoma, A549 lung cancer, HaCaT immortalized keratinocyte, HeLa cervical carcinoma, and Saos-2 osteosarcoma) |
| 10652205 | In contrast, among the human tissues examined, the heart and brain, which contain a large number of post-mitotic cells, showed the highest expression of REIC |
| 10652205 | The full-length REIC cDNA revealed that the predicted protein is 350 amino acids in length and possesses coiled-coil tertiary structures in each of the amino- and carboxyl-termini |
| 10652205 | Furthermore, a search of the protein database revealed a match of this gene product with Dkk-3, which is a novel inhibitor of Wnt oncogene |
| 10652205 | These results indicate that the REIC cloned by us may function as a tumor suppressor |
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