HCSGD entry for DKK4
1. General information
| Official gene symbol | DKK4 |
|---|---|
| Entrez ID | 27121 |
| Gene full name | dickkopf WNT signaling pathway inhibitor 4 |
| Other gene symbols | DKK-4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7171853159 | 0.7415206565 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0234563864 |
| GSE13712_SHEAR | Down | -0.0969193276 |
| GSE13712_STATIC | Down | -0.0064756664 |
| GSE19018 | Up | 0.1708226887 |
| GSE19899_A1 | Down | -0.0248765697 |
| GSE19899_A2 | Up | 0.1801735445 |
| PubMed_21979375_A1 | Down | -0.0888762916 |
| PubMed_21979375_A2 | Down | -0.1169923907 |
| GSE35957 | Down | -0.1282527048 |
| GSE36640 | Up | 0.0600524204 |
| GSE54402 | Up | 0.1268545384 |
| GSE9593 | Up | 0.1930161566 |
| GSE43922 | Up | 0.0122857641 |
| GSE24585 | Up | 0.1271212443 |
| GSE37065 | Down | -0.0137272503 |
| GSE28863_A1 | Down | -0.2609680968 |
| GSE28863_A2 | Down | -0.0391958162 |
| GSE28863_A3 | Down | -0.0117331962 |
| GSE28863_A4 | Up | 0.0977889841 |
| GSE48662 | Up | 0.0862119772 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017610 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050225 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24286133 | Moreover, transfection with DKK-3, DKK-4, or SOST, which are inhibitors of Wnt signaling, blocked Wnt signaling-mediated TNF-alpha activation; these effects were not observed for DKK-1 or DKK-2 |
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