HCSGD entry for EIF2AK1
1. General information
| Official gene symbol | EIF2AK1 |
|---|---|
| Entrez ID | 27102 |
| Gene full name | eukaryotic translation initiation factor 2-alpha kinase 1 |
| Other gene symbols | HCR HRI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003743 | Translation initiation factor activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004694 | Eukaryotic translation initiation factor 2alpha kinase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006950 | Response to stress | IEP | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0009605 | Response to external stimulus | IEP | biological_process |
| GO:0010999 | Regulation of eIF2 alpha phosphorylation by heme | IEA | biological_process |
| GO:0020037 | Heme binding | ISS | molecular_function |
| GO:0042803 | Protein homodimerization activity | ISS | molecular_function |
| GO:0045993 | Negative regulation of translational initiation by iron | NAS | biological_process |
| GO:0046501 | Protoporphyrinogen IX metabolic process | IEA | biological_process |
| GO:0046777 | Protein autophosphorylation | ISS | biological_process |
| GO:0046986 | Negative regulation of hemoglobin biosynthetic process | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7162353330 | 0.1502747464 | 0.9999902473 | 0.7494091701 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1964727282 |
| GSE13712_SHEAR | Down | -0.4464578975 |
| GSE13712_STATIC | Down | -0.5454577852 |
| GSE19018 | Down | -0.0454373409 |
| GSE19899_A1 | Down | -0.3001036044 |
| GSE19899_A2 | Down | -0.3223943303 |
| PubMed_21979375_A1 | Up | 0.2821665911 |
| PubMed_21979375_A2 | Up | 0.0520244395 |
| GSE35957 | Down | -0.3008108005 |
| GSE36640 | Down | -0.0705630767 |
| GSE54402 | Up | 0.0761393945 |
| GSE9593 | Up | 0.2079549197 |
| GSE43922 | Up | 0.0138367135 |
| GSE24585 | Up | 0.1567552620 |
| GSE37065 | Down | -0.1691365611 |
| GSE28863_A1 | Up | 0.0170022276 |
| GSE28863_A2 | Up | 0.4630612976 |
| GSE28863_A3 | Down | -0.4384470940 |
| GSE28863_A4 | Down | -0.4347878347 |
| GSE48662 | Up | 0.3722535961 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT024150 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025934 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038895 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040713 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049608 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052113 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
