HCSGD entry for NOX1

1. General information

Official gene symbolNOX1
Entrez ID27035
Gene full nameNADPH oxidase 1
Other gene symbolsGP91-2 MOX1 NOH-1 NOH1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIMPbiological_process
GO:0003081Regulation of systemic arterial blood pressure by renin-angiotensinIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005769Early endosomeIDAcellular_component
GO:0006739NADP metabolic processICbiological_process
GO:0006801Superoxide metabolic processIMPbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008217Regulation of blood pressureTASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0009268Response to pHIDAbiological_process
GO:0010575Positive regulation vascular endothelial growth factor productionIEPbiological_process
GO:0015992Proton transportIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIC IEAcellular_component
GO:0016175Superoxide-generating NADPH oxidase activityIC TASmolecular_function
GO:0016477Cell migrationIMPbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030171Voltage-gated proton channel activityIDAmolecular_function
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0042554Superoxide anion generationIDAbiological_process
GO:0042743Hydrogen peroxide metabolic processIDAbiological_process
GO:0043020NADPH oxidase complexIDAcellular_component
GO:0045726Positive regulation of integrin biosynthetic processIMPbiological_process
GO:0045730Respiratory burstTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048365Rac GTPase bindingIPImolecular_function
GO:0048661Positive regulation of smooth muscle cell proliferationISSbiological_process
GO:0050661NADP bindingICmolecular_function
GO:0051454Intracellular pH elevationIDAbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0071438Invadopodium membraneIDAcellular_component
GO:0071468Cellular response to acidityIDAbiological_process
GO:0072592Oxygen metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79497980700.90503630560.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0050048074
GSE13712_SHEARUp0.0179194056
GSE13712_STATICDown-0.0649195041
GSE19018Up0.0420677800
GSE19899_A1Up0.0407931982
GSE19899_A2Up0.1279694026
PubMed_21979375_A1Up0.0543618433
PubMed_21979375_A2Up0.1401115841
GSE35957Up0.1167242033
GSE36640Up0.0842645708
GSE54402Up0.0692169711
GSE9593Down-0.0008254759
GSE43922Up0.0020598840
GSE24585Up0.1148313733
GSE37065Down-0.0764430919
GSE28863_A1Down-0.0367304122
GSE28863_A2Up0.0325033011
GSE28863_A3Up0.1146433900
GSE28863_A4Down-0.0231462519
GSE48662Up0.0065600931

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25982278Using human and mouse normal and cancer cell models, we now show that TNFalpha and IFNgamma induce NADPH oxidases Nox4 and Nox1, reactive oxygen species (ROS), DDR signaling and premature senescence
25982278Unlike mouse tumor cells that required concomitant presence of IFNgamma and TNFalpha, short exposure to IFNgamma alone was sufficient to induce Nox4, Nox1 and DDR in human cells
23216904ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence
23216904Here, we show that through the Ras/MEK pathway, Ras oncogene up-regulated the expression of superoxide-generating oxidases, Nox1 in rat REF52 cells and Nox4 in primary human lung TIG-3 cells, leading to an increase in intracellular level of ROS
23216904Ablation of Nox1 and Nox4 by small interfering RNAs (siRNAs) blocked the RasV12 senescent phenotype including beta-galactosidase activity, growth arrest and accumulation of tumor suppressors such as p53 and p16Ink4a
23216904Furthermore, Nox1 and Nox4 siRNAs inhibited both Ras-induced DNA damage response and p38MAPK activation, whereas overexpression of Nox1 and Nox4 alone was able to induce senescence
23216904The involvement of Nox1 in Ras-induced senescence was also confirmed with embryonic fibroblasts derived from Nox1 knockout mice
23216904Together, these findings suggest that Nox1- and Nox4-generated ROS play an important role in Ras-induced premature senescence, which may involve DNA damage response and p38MAPK signaling pathways
21841319There were no significant changes in NOX1 or NOX3
20523116Our study revealed that normal breast tissues express NOX1, 4 and 5 genes
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