HCSGD entry for MLH3
1. General information
| Official gene symbol | MLH3 |
|---|---|
| Entrez ID | 27030 |
| Gene full name | mutL homolog 3 (E. coli) |
| Other gene symbols | HNPCC7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000795 | Synaptonemal complex | IBA IEA | cellular_component |
| GO:0001673 | Male germ cell nucleus | IEA | cellular_component |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003696 | Satellite DNA binding | TAS | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005712 | Chiasma | IBA IEA | cellular_component |
| GO:0006200 | ATP catabolic process | IBA | biological_process |
| GO:0006298 | Mismatch repair | IBA IEA NAS | biological_process |
| GO:0007130 | Synaptonemal complex assembly | IEA | biological_process |
| GO:0007131 | Reciprocal meiotic recombination | IBA NAS | biological_process |
| GO:0007140 | Male meiosis | IEA | biological_process |
| GO:0007144 | Female meiosis I | IEA | biological_process |
| GO:0008104 | Protein localization | IEA | biological_process |
| GO:0016887 | ATPase activity | IBA | molecular_function |
| GO:0019237 | Centromeric DNA binding | IEA | molecular_function |
| GO:0030983 | Mismatched DNA binding | IEA | molecular_function |
| GO:0032300 | Mismatch repair complex | IBA | cellular_component |
| GO:0032390 | MutLbeta complex | IBA | cellular_component |
| GO:0032407 | MutSalpha complex binding | IBA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0332281296 | 0.9494500285 | 0.4190870875 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1199891370 |
| GSE13712_SHEAR | Up | 0.4099040520 |
| GSE13712_STATIC | Up | 0.1293806911 |
| GSE19018 | Up | 0.1649833842 |
| GSE19899_A1 | Down | -0.1138711035 |
| GSE19899_A2 | Up | 0.2521348935 |
| PubMed_21979375_A1 | Up | 0.9467184087 |
| PubMed_21979375_A2 | Up | 0.9751765601 |
| GSE35957 | Down | -0.2461472415 |
| GSE36640 | Up | 0.1351350586 |
| GSE54402 | Up | 0.4730897313 |
| GSE9593 | Up | 0.0081989511 |
| GSE43922 | Up | 0.0533989062 |
| GSE24585 | Down | -0.2375221305 |
| GSE37065 | Up | 0.3976172836 |
| GSE28863_A1 | Up | 0.5573646455 |
| GSE28863_A2 | Up | 0.5277950552 |
| GSE28863_A3 | Down | -0.0177254189 |
| GSE28863_A4 | Down | -0.0261202516 |
| GSE48662 | Up | 0.1305743704 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-3p | MIMAT0004679 | MIRT038410 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039929 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041797 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT043606 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
