HCSGD entry for GJA8
1. General information
| Official gene symbol | GJA8 |
|---|---|
| Entrez ID | 2703 |
| Gene full name | gap junction protein, alpha 8, 50kDa |
| Other gene symbols | CAE CAE1 CTRCT1 CX50 CZP1 MP70 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002088 | Lens development in camera-type eye | IEA | biological_process |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005922 | Connexon complex | IEA | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | IEA | biological_process |
| GO:0007601 | Visual perception | TAS | biological_process |
| GO:0015267 | Channel activity | TAS | molecular_function |
| GO:0051260 | Protein homooligomerization | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3581607006 | 0.7359138559 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0010890733 |
| GSE13712_SHEAR | Up | 0.0211789639 |
| GSE13712_STATIC | Up | 0.2583818719 |
| GSE19018 | Down | -0.2295042220 |
| GSE19899_A1 | Down | -0.0160687578 |
| GSE19899_A2 | Up | 0.1342299988 |
| PubMed_21979375_A1 | Down | -0.3321276860 |
| PubMed_21979375_A2 | Down | -0.1321660129 |
| GSE35957 | Up | 0.1333765667 |
| GSE36640 | Up | 0.0764581043 |
| GSE54402 | Up | 0.0070731294 |
| GSE9593 | Down | -0.0604943460 |
| GSE43922 | Up | 0.0287042601 |
| GSE24585 | Down | -0.0337525401 |
| GSE37065 | Up | 0.1454220111 |
| GSE28863_A1 | Up | 0.0123268513 |
| GSE28863_A2 | Up | 0.1308780555 |
| GSE28863_A3 | Up | 0.2938208410 |
| GSE28863_A4 | Up | 0.3933493248 |
| GSE48662 | Up | 0.0452085186 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018805 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23801922 | SUMMARY: The ubiquitously expressed cell surface glycoprotein CD47 is expressed by virtually all cells in the host, where it can function to regulate integrin-mediated responses, or constitute an important part of the erythrocyte band 3/Rh multi-protein complex |
| 14604992 | Following hSNF5 expression, we observed transcriptional activation of the tumor suppressor p16(INK4a) but not of p14(ARF), repression of several cyclins and CD44, a cell surface glycoprotein implicated in metastasis |
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