HCSGD entry for ABL2

1. General information

Official gene symbolABL2
Entrez ID27
Gene full namev-abl Abelson murine leukemia viral oncogene homolog 2
Other gene symbolsABLL ARG
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0003785Actin monomer bindingTASmolecular_function
GO:0004672Protein kinase activityTASmolecular_function
GO:0004713Protein tyrosine kinase activityIDAmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0010506Regulation of autophagyTASbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0015629Actin cytoskeletonTAScellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0030100Regulation of endocytosisTASbiological_process
GO:0030145Manganese ion bindingIDAmolecular_function
GO:0030155Regulation of cell adhesionTASbiological_process
GO:0051015Actin filament bindingTASmolecular_function
GO:0051017Actin filament bundle assemblyIEAbiological_process
GO:0051353Positive regulation of oxidoreductase activityIDAbiological_process
GO:0071300Cellular response to retinoic acidIMPbiological_process
GO:2000145Regulation of cell motilityTASbiological_process
GO:2000249Regulation of actin cytoskeleton reorganizationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02513859660.61270822540.37282093421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0677853385
GSE13712_SHEARUp0.4242471007
GSE13712_STATICUp0.1066508212
GSE19018Down-0.4411540912
GSE19899_A1Up0.4716806768
GSE19899_A2Up0.4138004506
PubMed_21979375_A1Up1.1370915300
PubMed_21979375_A2Up1.0762054623
GSE35957Down-0.1568938524
GSE36640Up0.1469101202
GSE54402Up0.5654436463
GSE9593Up0.5794469259
GSE43922Up0.0223181182
GSE24585Down-0.1249158149
GSE37065Up0.0702910558
GSE28863_A1Down-0.2063573087
GSE28863_A2Up1.0686917987
GSE28863_A3Down-0.2133190269
GSE28863_A4Down-0.4022150982
GSE48662Down-0.0130945572

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
DasatinibDB01254 -
XL228DB05184 -
5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDEDB07664 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-140-3pMIMAT0004597MIRT021668SequencingFunctional MTI (Weak)20371350
hsa-miR-103a-3pMIMAT0000101MIRT027023SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031452SequencingFunctional MTI (Weak)20371350
hsa-miR-92a-3pMIMAT0000092MIRT049012CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.