HCSGD entry for GHR

1. General information

Official gene symbolGHR
Entrez ID2690
Gene full namegrowth hormone receptor
Other gene symbolsGHBP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIEA ISSbiological_process
GO:0000255Allantoin metabolic processISSbiological_process
GO:0004903Growth hormone receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDA IEA IMPcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006101Citrate metabolic processISSbiological_process
GO:00061032-oxoglutarate metabolic processISSbiological_process
GO:0006105Succinate metabolic processISSbiological_process
GO:0006107Oxaloacetate metabolic processISSbiological_process
GO:0006549Isoleucine metabolic processISSbiological_process
GO:0006573Valine metabolic processISSbiological_process
GO:0006600Creatine metabolic processISSbiological_process
GO:0006631Fatty acid metabolic processISSbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0007259JAK-STAT cascadeIEA ISSbiological_process
GO:0009755Hormone-mediated signaling pathwayIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0017046Peptide hormone bindingIEA IPImolecular_function
GO:0019530Taurine metabolic processISSbiological_process
GO:0019838Growth factor bindingIPImolecular_function
GO:0019898Extrinsic component of membraneIEAcellular_component
GO:0019901Protein kinase bindingIEA ISSmolecular_function
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0031623Receptor internalizationIDAbiological_process
GO:0032094Response to foodIEAbiological_process
GO:0032355Response to estradiolIDAbiological_process
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0032870Cellular response to hormone stimulusIMPbiological_process
GO:0040014Regulation of multicellular organism growthISSbiological_process
GO:0040018Positive regulation of multicellular organism growthIMPbiological_process
GO:0042169SH2 domain bindingIEAmolecular_function
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinISSbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinISSbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042977Activation of JAK2 kinase activityIEA ISSbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0043278Response to morphineIEAbiological_process
GO:0044236Multicellular organismal metabolic processIMPbiological_process
GO:0045597Positive regulation of cell differentiationIEAbiological_process
GO:0046449Creatinine metabolic processISSbiological_process
GO:0046898Response to cycloheximideIDAbiological_process
GO:0048009Insulin-like growth factor receptor signaling pathwayIMPbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationISSbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0060351Cartilage development involved in endochondral bone morphogenesisIEAbiological_process
GO:0060396Growth hormone receptor signaling pathwayIEA IMPbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0070064Proline-rich region bindingISSmolecular_function
GO:0070195Growth hormone receptor complexIDAcellular_component
GO:0070555Response to interleukin-1IEAbiological_process
GO:1901215Negative regulation of neuron deathIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.36593276850.02689631850.99999024730.3137899646

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4477077210
GSE13712_SHEARDown-0.7252391061
GSE13712_STATICDown-0.4665448345
GSE19018Down-0.3469034367
GSE19899_A1Down-0.0550183402
GSE19899_A2Down-0.7876226196
PubMed_21979375_A1Up0.0686864949
PubMed_21979375_A2Up0.0247528608
GSE35957Up0.6311030422
GSE36640Up2.9416350779
GSE54402Down-0.4189774493
GSE9593Up0.2727087943
GSE43922Down-0.5716861556
GSE24585Down-0.0644218954
GSE37065Down-0.1782531934
GSE28863_A1Down-0.4680237386
GSE28863_A2Down-0.1408345217
GSE28863_A3Down-0.0857585630
GSE28863_A4Down-0.0958934987
GSE48662Up0.1388350082

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Somatropin recombinantDB00052 BTD00086 | BIOD00086
PegvisomantDB00082 BTD00044 | BIOD00044

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26372907Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence
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