HCSGD entry for GFPT1

1. General information

Official gene symbolGFPT1
Entrez ID2673
Gene full nameglutamine--fructose-6-phosphate transaminase 1
Other gene symbolsCMSTA1 GFA GFAT GFAT 1 GFAT1 GFAT1m GFPT GFPT1L MSLG
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004360Glutamine-fructose-6-phosphate transaminase (isomerizing) activityIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006002Fructose 6-phosphate metabolic processIEAbiological_process
GO:0006042Glucosamine biosynthetic processIEAbiological_process
GO:0006048UDP-N-acetylglucosamine biosynthetic processIEA TASbiological_process
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006488Dolichol-linked oligosaccharide biosynthetic processTASbiological_process
GO:0006541Glutamine metabolic processIEAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0009744Response to sucroseIEAbiological_process
GO:0016051Carbohydrate biosynthetic processIEAbiological_process
GO:0016597Amino acid bindingIEAmolecular_function
GO:0018279Protein N-linked glycosylation via asparagineTASbiological_process
GO:0030246Carbohydrate bindingIEAmolecular_function
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045719Negative regulation of glycogen biosynthetic processIEAbiological_process
GO:0051289Protein homotetramerizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03284889630.96812576650.41789067181.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0756458018
GSE13712_SHEARDown-0.2276871060
GSE13712_STATICDown-0.0642935230
GSE19018Up0.3265325472
GSE19899_A1Up0.6182113752
GSE19899_A2Up0.2544098833
PubMed_21979375_A1Up0.1613150251
PubMed_21979375_A2Up0.4199720084
GSE35957Up0.3679946465
GSE36640Up0.8598090204
GSE54402Up0.0705920671
GSE9593Up0.5862369516
GSE43922Up0.1866710968
GSE24585Down-0.0681178791
GSE37065Up0.0216828229
GSE28863_A1Up0.1204293735
GSE28863_A2Up0.7369567840
GSE28863_A3Down-0.3184234025
GSE28863_A4Down-0.1798659500
GSE48662Up0.1515385062

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001464pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-590-3pMIMAT0004801MIRT016186SequencingFunctional MTI (Weak)20371350
hsa-miR-335-5pMIMAT0000765MIRT017993MicroarrayFunctional MTI (Weak)18185580
hsa-miR-34a-5pMIMAT0000255MIRT025445ProteomicsFunctional MTI (Weak)21566225
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

2870196Glial cell cultures derived from newborn and aged (18-month-old) mouse cerebral hemispheres and maintained up to cell passage 11 were characterized immunocytochemically by using glial fibrillary acidic protein (GFA), and biochemically by using glutamine synthetase (GS), for astrocytes, and 2',3' cyclic nucleotide 3' phosphohydrolase (CNP) for oligodendrocytes
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