HCSGD entry for GEM
1. General information
| Official gene symbol | GEM |
|---|---|
| Entrez ID | 2669 |
| Gene full name | GTP binding protein overexpressed in skeletal muscle |
| Other gene symbols | KIR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0003924 | GTPase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005525 | GTP binding | IDA IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007067 | Mitosis | IMP | biological_process |
| GO:0007165 | Signal transduction | IEA TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0009898 | Cytoplasmic side of plasma membrane | IDA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0051233 | Spindle midzone | IDA | cellular_component |
| GO:0051276 | Chromosome organization | IMP | biological_process |
| GO:0072686 | Mitotic spindle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0043258957 | 0.0440598799 | 0.1760215926 | 0.3947243363 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6201774777 |
| GSE13712_SHEAR | Up | 0.3741727653 |
| GSE13712_STATIC | Up | 0.8795751322 |
| GSE19018 | Down | -2.8375770029 |
| GSE19899_A1 | Up | 2.4125442580 |
| GSE19899_A2 | Down | -0.6239910074 |
| PubMed_21979375_A1 | Up | 0.8924011587 |
| PubMed_21979375_A2 | Up | 0.1267536342 |
| GSE35957 | Down | -0.7600057943 |
| GSE36640 | Down | -1.8803441472 |
| GSE54402 | Up | 0.5062111957 |
| GSE9593 | Up | 0.1807917204 |
| GSE43922 | Up | 1.0577458494 |
| GSE24585 | Down | -0.0646262330 |
| GSE37065 | Up | 0.7089207693 |
| GSE28863_A1 | Up | 0.3343999873 |
| GSE28863_A2 | Up | 1.0908210834 |
| GSE28863_A3 | Down | -0.2793571196 |
| GSE28863_A4 | Up | 0.0337171886 |
| GSE48662 | Down | -0.3993754658 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017623 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029336 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
