HCSGD entry for CKAP2
1. General information
| Official gene symbol | CKAP2 |
|---|---|
| Entrez ID | 26586 |
| Gene full name | cytoskeleton associated protein 2 |
| Other gene symbols | LB1 TMAP se20-10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000281 | Mitotic cytokinesis | IGI | biological_process |
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005881 | Cytoplasmic microtubule | IDA IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007026 | Negative regulation of microtubule depolymerization | IEA | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IGI | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7515616694 | 0.0029016869 | 0.9999902473 | 0.1074195499 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4676301257 |
| GSE13712_SHEAR | Down | -0.0742216759 |
| GSE13712_STATIC | Up | 0.0083540416 |
| GSE19018 | Up | 0.3102230484 |
| GSE19899_A1 | Down | -0.4226224188 |
| GSE19899_A2 | Down | -0.9107512407 |
| PubMed_21979375_A1 | Down | -1.1816020777 |
| PubMed_21979375_A2 | Down | -1.2296534988 |
| GSE35957 | Down | -0.8394427237 |
| GSE36640 | Down | -1.1526793801 |
| GSE54402 | Down | -0.5338646051 |
| GSE9593 | Down | -0.2668661686 |
| GSE43922 | Down | -1.0612420817 |
| GSE24585 | Up | 0.4189041673 |
| GSE37065 | Down | -0.1243941755 |
| GSE28863_A1 | Down | -0.3436618242 |
| GSE28863_A2 | Up | 0.8923658960 |
| GSE28863_A3 | Down | -0.7992507348 |
| GSE28863_A4 | Up | 0.5722266159 |
| GSE48662 | Down | -0.7272075914 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019751 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046745 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048321 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052226 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22155925 | Nuclear lamin B1 (LB1) is a major structural component of the nucleus that appears to be involved in the regulation of many nuclear functions |
| 22155925 | The results of this study demonstrate that LB1 expression in WI-38 cells decreases during cellular senescence |
| 22155925 | Premature senescence induced by oncogenic Ras also decreases LB1 expression through a retinoblastoma protein (pRb)-dependent mechanism |
| 22155925 | The effects of LB1 silencing on proliferation require the activation of p53, but not pRb |
| 22155925 | The proliferation defects induced by silencing LB1 are accompanied by a p53-dependent reduction in mitochondrial reactive oxygen species (ROS), which can be rescued by growth under hypoxic conditions |
| 22155925 | In contrast to the effects of LB1 silencing, overexpression of LB1 increases the proliferation rate and delays the onset of senescence of WI-38 cells |
| 22155925 | These results demonstrate the importance of LB1 in regulating the proliferation and senescence of human diploid cells through a ROS signaling pathway |
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