HCSGD entry for GREM1

1. General information

Official gene symbolGREM1
Entrez ID26585
Gene full namegremlin 1, DAN family BMP antagonist
Other gene symbolsCKTSF1B1 DAND2 DRM GREMLIN IHG-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000902Cell morphogenesisIDAbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0002042Cell migration involved in sprouting angiogenesisISSbiological_process
GO:0002092Positive regulation of receptor internalizationISSbiological_process
GO:0003257Positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationISSbiological_process
GO:0003337Mesenchymal to epithelial transition involved in metanephros morphogenesisIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceNAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionISSbiological_process
GO:0007171Activation of transmembrane receptor protein tyrosine kinase activityISSbiological_process
GO:0007267Cell-cell signalingIEAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0009954Proximal/distal pattern formationIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010717Regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0016015Morphogen activityISSmolecular_function
GO:0030199Collagen fibril organizationIMPbiological_process
GO:0030297Transmembrane receptor protein tyrosine kinase activator activityISSmolecular_function
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0030502Negative regulation of bone mineralizationIMPbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIDA IMPbiological_process
GO:0032872Regulation of stress-activated MAPK cascadeISSbiological_process
GO:0033689Negative regulation of osteoblast proliferationIMPbiological_process
GO:0036122BMP bindingISSmolecular_function
GO:0042346Positive regulation of NF-kappaB import into nucleusIEAbiological_process
GO:0043184Vascular endothelial growth factor receptor 2 bindingISSmolecular_function
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046851Negative regulation of bone remodelingIMPbiological_process
GO:0048018Receptor agonist activityISSmolecular_function
GO:0048263Determination of dorsal identityIMPbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEAbiological_process
GO:0051893Regulation of focal adhesion assemblyIEAbiological_process
GO:0051973Positive regulation of telomerase activityIDAbiological_process
GO:0060394Negative regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060676Ureteric bud formationIEAbiological_process
GO:0072331Signal transduction by p53 class mediatorISSbiological_process
GO:0090027Negative regulation of monocyte chemotaxisISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0090191Negative regulation of branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0090291Negative regulation of osteoclast proliferationIMPbiological_process
GO:1900086Positive regulation of peptidyl-tyrosine autophosphorylationISSbiological_process
GO:1900155Negative regulation of bone trabecula formationIMPbiological_process
GO:1900158Negative regulation of bone mineralization involved in bone maturationIMPbiological_process
GO:2000273Positive regulation of receptor activityISSbiological_process
GO:2000727Positive regulation of cardiac muscle cell differentiationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97255351240.00194474370.99999024730.0846848435

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1456820574
GSE13712_SHEARDown-0.0294855151
GSE13712_STATICUp0.1611265738
GSE19018Up0.1122647689
GSE19899_A1Down-0.8918017004
GSE19899_A2Down-1.2114888668
PubMed_21979375_A1Down-2.0521920619
PubMed_21979375_A2Down-1.2614965199
GSE35957Up0.6174559768
GSE36640Down-0.7088179183
GSE54402Down-0.1310807960
GSE9593Up0.3846589835
GSE43922Down-1.0146615769
GSE24585Down-0.0356345646
GSE37065Down-0.5932123050
GSE28863_A1Down-0.2977162252
GSE28863_A2Down-0.1749458883
GSE28863_A3Down-0.2335975314
GSE28863_A4Down-0.2343390336
GSE48662Down-1.7184060278

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022737MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26690900Menon from the Department of Obstetrics and Gynecology at The University of Texas Medical Branch at Galveston and funds to Dr M
16303768Although total levels of both structural components of DRMs were up-regulated in aged cells, their particular DRM association was decreased
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