HCSGD entry for GDF2

1. General information

Official gene symbolGDF2
Entrez ID2658
Gene full namegrowth differentiation factor 2
Other gene symbolsBMP-9 BMP9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationTASbiological_process
GO:0001569Patterning of blood vesselsIDAbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIDAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0006879Cellular iron ion homeostasisTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008156Negative regulation of DNA replicationTASbiological_process
GO:0010596Negative regulation of endothelial cell migrationIDAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0016525Negative regulation of angiogenesisTASbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032924Activin receptor signaling pathwayIDAbiological_process
GO:0040007GrowthIEAbiological_process
GO:0043537Negative regulation of blood vessel endothelial cell migrationTASbiological_process
GO:0045603Positive regulation of endothelial cell differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048514Blood vessel morphogenesisIDAbiological_process
GO:0051216Cartilage developmentTASbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:2000279Negative regulation of DNA biosynthetic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77038761830.54170728320.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1388762802
GSE13712_SHEARDown-0.0334839487
GSE13712_STATICDown-0.0006196112
GSE19018Up0.1865003666
GSE19899_A1Down-0.0518941301
GSE19899_A2Up0.0499308210
PubMed_21979375_A1Down-0.1516116513
PubMed_21979375_A2Down-0.0476951684
GSE35957Down-0.1816644690
GSE36640Up0.0631493163
GSE54402Up0.0087899849
GSE9593Down-0.1084696751
GSE43922Up0.0925289748
GSE24585Up0.1492570707
GSE37065Down-0.0743816567
GSE28863_A1Down-0.3254760559
GSE28863_A2Down-0.1362926872
GSE28863_A3Up0.2660457665
GSE28863_A4Up0.1929074276
GSE48662Up0.0390284873

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25279424Members of the TGF-beta superfamily, TGF-beta1, TGF-beta3, and BMP9, are key propagators of both inhibition and initiation of angiogenesis
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