HCSGD entry for AATF

1. General information

Official gene symbolAATF
Entrez ID26574
Gene full nameapoptosis antagonizing transcription factor
Other gene symbolsCHE-1 CHE1 DED
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006974Cellular response to DNA damage stimulusIEPbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007346Regulation of mitotic cell cycleIEAbiological_process
GO:0032929Negative regulation of superoxide anion generationIDAbiological_process
GO:0040016Embryonic cleavageIEAbiological_process
GO:0042254Ribosome biogenesisIEAbiological_process
GO:0042985Negative regulation of amyloid precursor protein biosynthetic processIEAbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043522Leucine zipper domain bindingIEA IPImolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048156Tau protein bindingIEAmolecular_function
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:2000378Negative regulation of reactive oxygen species metabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16886907410.54032783710.80946673941.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3476244136
GSE13712_SHEARDown-0.0674943136
GSE13712_STATICUp0.1771645333
GSE19018Down-0.3684526412
GSE19899_A1Up0.0249586115
GSE19899_A2Up0.2962910344
PubMed_21979375_A1Up0.8109909423
PubMed_21979375_A2Up0.6397455532
GSE35957Down-0.7427271593
GSE36640Down-0.5721996574
GSE54402Up0.2377924809
GSE9593Up0.1718445521
GSE43922Up0.0483563904
GSE24585Down-0.7123241468
GSE37065Up0.0366804251
GSE28863_A1Up0.2059767522
GSE28863_A2Up0.1622848425
GSE28863_A3Up0.1215678939
GSE28863_A4Up0.1713585664
GSE48662Down-0.0224345339

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022994Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-151a-3pMIMAT0000757MIRT043604CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045596CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052353CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.