HCSGD entry for HEYL

1. General information

Official gene symbolHEYL
Entrez ID26508
Gene full namehairy/enhancer-of-split related with YRPW motif-like
Other gene symbolsHESR3 HEY3 HRT3 bHLHb33
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityIEA ISSmolecular_function
GO:0000988Protein binding transcription factor activityIDAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001106RNA polymerase II transcription corepressor activityIEAmolecular_function
GO:0003151Outflow tract morphogenesisIEA ISSbiological_process
GO:0003181Atrioventricular valve morphogenesisIEA ISSbiological_process
GO:0003184Pulmonary valve morphogenesisIEA ISSbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationIEA ISSbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003208Cardiac ventricle morphogenesisIEA ISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007219Notch signaling pathwayIDA TASbiological_process
GO:0008134Transcription factor bindingNASmolecular_function
GO:0014031Mesenchymal cell developmentISSbiological_process
GO:0032835Glomerulus developmentIEAbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0035939Microsatellite bindingIDAmolecular_function
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0045666Positive regulation of neuron differentiationIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0050683AF-1 domain bindingIPImolecular_function
GO:0060317Cardiac epithelial to mesenchymal transitionISSbiological_process
GO:0060412Ventricular septum morphogenesisIEA ISSbiological_process
GO:0060766Negative regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0071773Cellular response to BMP stimulusIEAbiological_process
GO:0072014Proximal tubule developmentIEAbiological_process
GO:2000824Negative regulation of androgen receptor activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.64782816380.58300775050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0344654709
GSE13712_SHEARDown-0.1795239160
GSE13712_STATICDown-0.2527754307
GSE19018Down-0.0641817043
GSE19899_A1Up0.0605762521
GSE19899_A2Up0.2236013774
PubMed_21979375_A1Up0.0835115158
PubMed_21979375_A2Up0.1425328142
GSE35957Down-0.0745586689
GSE36640Down-0.1636692338
GSE54402Down-0.0103695701
GSE9593Down-0.4485031218
GSE43922Up0.0263122221
GSE24585Up0.2776966657
GSE37065Down-0.0441981652
GSE28863_A1Up0.0090505538
GSE28863_A2Up0.0673081507
GSE28863_A3Up0.2167972902
GSE28863_A4Up0.1324076775
GSE48662Down-0.0224908238

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-3pMIMAT0004509MIRT038777CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.