HCSGD entry for NR6A1
1. General information
| Official gene symbol | NR6A1 |
|---|---|
| Entrez ID | 2649 |
| Gene full name | nuclear receptor subfamily 6, group A, member 1 |
| Other gene symbols | GCNF GCNF1 NR61 RTR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0003677 | DNA binding | ISS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | ISS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007276 | Gamete generation | ISS | biological_process |
| GO:0007283 | Spermatogenesis | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030522 | Intracellular receptor signaling pathway | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | ISS | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8002356711 | 0.9097751605 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0262161398 |
| GSE13712_SHEAR | Up | 0.0201490807 |
| GSE13712_STATIC | Up | 0.0082922883 |
| GSE19018 | Up | 0.1853277337 |
| GSE19899_A1 | Up | 0.0569340925 |
| GSE19899_A2 | Up | 0.1121631199 |
| PubMed_21979375_A1 | Up | 0.1067434234 |
| PubMed_21979375_A2 | Down | -0.0285572466 |
| GSE35957 | Up | 0.2381907579 |
| GSE36640 | Up | 0.1090494729 |
| GSE54402 | Up | 0.0234115362 |
| GSE9593 | Up | 0.0159957743 |
| GSE43922 | Up | 0.0166736165 |
| GSE24585 | Down | -0.0675233568 |
| GSE37065 | Up | 0.0181547341 |
| GSE28863_A1 | Down | -0.0864060712 |
| GSE28863_A2 | Down | -0.0616528321 |
| GSE28863_A3 | Up | 0.0413009824 |
| GSE28863_A4 | Up | 0.0155280870 |
| GSE48662 | Down | -0.0101299933 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-421 | MIMAT0003339 | MIRT016117 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021417 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025188 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
