HCSGD entry for GCKR

1. General information

Official gene symbolGCKR
Entrez ID2646
Gene full nameglucokinase (hexokinase 4) regulator
Other gene symbolsFGQTL5 GKRP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000060Protein import into nucleus, translocationIEA ISSbiological_process
GO:0001678Cellular glucose homeostasisIEAbiological_process
GO:0004857Enzyme inhibitor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmIEA ISS TAScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005975Carbohydrate metabolic processIEA TASbiological_process
GO:0008645Hexose transportTASbiological_process
GO:0009750Response to fructoseIDA IEAbiological_process
GO:0010827Regulation of glucose transportTASbiological_process
GO:0015758Glucose transportTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0019899Enzyme bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030246Carbohydrate bindingIEAmolecular_function
GO:0033132Negative regulation of glucokinase activityIDA IEAbiological_process
GO:0033133Positive regulation of glucokinase activityIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046415Urate metabolic processIMPbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0070095Fructose-6-phosphate bindingIDAmolecular_function
GO:0070328Triglyceride homeostasisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23134252880.93037758440.91497621341.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0429777068
GSE13712_SHEARUp0.8796655815
GSE13712_STATICUp0.1892562801
GSE19018Up0.0855682603
GSE19899_A1Up0.0620930045
GSE19899_A2Up0.1582666570
PubMed_21979375_A1Up0.4294002519
PubMed_21979375_A2Down-0.1217620180
GSE35957Up0.2013717423
GSE36640Down-0.0349423740
GSE54402Up0.2112162132
GSE9593Up0.1189487161
GSE43922Up0.0187253379
GSE24585Up0.1466587512
GSE37065Up0.0096177935
GSE28863_A1Down-0.1560606340
GSE28863_A2Up0.1516781360
GSE28863_A3Up0.0956315774
GSE28863_A4Up0.0322995826
GSE48662Down-0.1201189813

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.