HCSGD entry for GCHFR
1. General information
| Official gene symbol | GCHFR |
|---|---|
| Entrez ID | 2644 |
| Gene full name | GTP cyclohydrolase I feedback regulator |
| Other gene symbols | GFRP HsT16933 P35 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004857 | Enzyme inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006809 | Nitric oxide biosynthetic process | TAS | biological_process |
| GO:0009890 | Negative regulation of biosynthetic process | IEA | biological_process |
| GO:0016597 | Amino acid binding | IEA | molecular_function |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0030425 | Dendrite | IDA | cellular_component |
| GO:0030742 | GTP-dependent protein binding | IEA | molecular_function |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0042133 | Neurotransmitter metabolic process | TAS | biological_process |
| GO:0042470 | Melanosome | IDA | cellular_component |
| GO:0043105 | Negative regulation of GTP cyclohydrolase I activity | IEA | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0044549 | GTP cyclohydrolase binding | IEA | molecular_function |
| GO:0046209 | Nitric oxide metabolic process | TAS | biological_process |
| GO:0050999 | Regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8302871395 | 0.0806096501 | 0.9999902473 | 0.5368741397 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0630562934 |
| GSE13712_SHEAR | Down | -1.2667989352 |
| GSE13712_STATIC | Down | -1.1287381436 |
| GSE19018 | Up | 0.0497003499 |
| GSE19899_A1 | Down | -0.2012764593 |
| GSE19899_A2 | Down | -0.5029129270 |
| PubMed_21979375_A1 | Down | -0.0032727353 |
| PubMed_21979375_A2 | Down | -0.3182475721 |
| GSE35957 | Down | -0.4441225113 |
| GSE36640 | Down | -0.0640381411 |
| GSE54402 | Down | -0.0959095259 |
| GSE9593 | Down | -0.4581764373 |
| GSE43922 | Up | 0.0311316187 |
| GSE24585 | Up | 0.2318741130 |
| GSE37065 | Up | 0.0596270956 |
| GSE28863_A1 | Down | -0.0613550749 |
| GSE28863_A2 | Down | -0.0517878180 |
| GSE28863_A3 | Up | 0.3408346613 |
| GSE28863_A4 | Up | 0.0736598054 |
| GSE48662 | Up | 0.1907515965 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048942 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
