HCSGD entry for HSPB8
1. General information
| Official gene symbol | HSPB8 |
|---|---|
| Entrez ID | 26353 |
| Gene full name | heat shock 22kDa protein 8 |
| Other gene symbols | CMT2L DHMN2 E2IG1 H11 HMN2 HMN2A HSP22 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006950 | Response to stress | IEA | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0977026937 | 0.4343972683 | 0.6532944120 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2775893374 |
| GSE13712_SHEAR | Up | 0.7610888877 |
| GSE13712_STATIC | Up | 0.4522247349 |
| GSE19018 | Up | 0.0591110225 |
| GSE19899_A1 | Down | -0.5695209445 |
| GSE19899_A2 | Down | -0.0323533440 |
| PubMed_21979375_A1 | Down | -0.5386303403 |
| PubMed_21979375_A2 | Down | -0.2328602538 |
| GSE35957 | Up | 0.2376613817 |
| GSE36640 | Up | 0.8525935875 |
| GSE54402 | Down | -0.1994879571 |
| GSE9593 | Up | 1.0495445061 |
| GSE43922 | Down | -0.3230618003 |
| GSE24585 | Up | 0.0927034035 |
| GSE37065 | Up | 0.4608913231 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.1398178231 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036507 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21681022 | BAG3 was recently described as a mediator of a novel macroautophagy pathway that uses the specificity of heat shock protein 70 (HSP70) to misfolded proteins and also involves other protein partners, such as HSPB8 |
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