HCSGD entry for EHF
1. General information
| Official gene symbol | EHF |
|---|---|
| Entrez ID | 26298 |
| Gene full name | ets homologous factor |
| Other gene symbols | ESE3 ESE3B ESEJ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005634 | Nucleus | IC IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0030855 | Epithelial cell differentiation | IEP | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000674442 | 0.9946766916 | 0.0224708861 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.2717115462 |
| GSE13712_SHEAR | Down | -0.0705960555 |
| GSE13712_STATIC | Down | -0.1049808761 |
| GSE19018 | Up | 0.1563475863 |
| GSE19899_A1 | Up | 1.5343696640 |
| GSE19899_A2 | Up | 4.2308997429 |
| PubMed_21979375_A1 | Up | 5.5243531456 |
| PubMed_21979375_A2 | Up | 3.3985664265 |
| GSE35957 | Up | 0.6398910176 |
| GSE36640 | Up | 1.7929388043 |
| GSE54402 | Up | 4.4873155705 |
| GSE9593 | Up | 0.0287093699 |
| GSE43922 | Up | 5.0885147819 |
| GSE24585 | Up | 0.1067490114 |
| GSE37065 | Up | 0.2408540503 |
| GSE28863_A1 | Down | -0.0585169081 |
| GSE28863_A2 | Up | 0.0570770094 |
| GSE28863_A3 | Up | 0.0958923401 |
| GSE28863_A4 | Up | 0.0324096824 |
| GSE48662 | Down | -0.0220607291 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017515 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17627613 | ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence |
| 17627613 | It was found that five genes encoding ESE-3, inhibin betaA, RGS5, SSAT and DIO2 were up-regulated in senescent cells induced by RasV12, H(2)O(2) and telomere shortening, but not in quiescent or actively growing cells, suggesting that these genes serve as molecular markers for various types of cellular senescence |
| 17627613 | The ectopic expression of ESE-3 resulted in retarded growth, up-regulation of p16(INK4a) but not of p21, and increased levels of SA-beta-gal activity |
| 17627613 | ESE-3 expression increased the activity of the p16(INK4a) promoter in a reporter assay, and recombinant ESE-3 protein bound to the Ets-binding sequences present in the promoter |
| 17172423 | Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis |
| 17172423 | In the process of identifying senescence-associated genes, we found significant suppression of the ets homologous factor (EHF) in cancer cells in a state of DNA damage-induced senescence |
| 17172423 | In this study, we show that EHF provides substantial drug resistance in PC-3 prostate cancer cells by inhibiting senescence and cell cycle arrest |
| 17172423 | Telomeric repeat amplification protocol analysis showed that transient EHF knockdown significantly decreased telomerase activity, whereas this activity was increased by overexpression of EHF |
| 17172423 | Further, the preestablished tumors were reduced after the injection of small interfering RNA corresponding to EHF (P = 0 |
| 17172423 | Collectively, these observations indicate that aberrant expression of EHF and the subsequent disruption of p27-mediated senescence and telomerase activity is likely to contribute significantly to tumor progression, and furthermore that EHF might be a promising target for future cancer therapeutics |
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