HCSGD entry for FGF21
1. General information
| Official gene symbol | FGF21 |
|---|---|
| Entrez ID | 26291 |
| Gene full name | fibroblast growth factor 21 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005104 | Fibroblast growth factor receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0010988 | Regulation of low-density lipoprotein particle clearance | NAS | biological_process |
| GO:0045716 | Positive regulation of low-density lipoprotein particle receptor biosynthetic process | NAS | biological_process |
| GO:0046326 | Positive regulation of glucose import | IDA | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IDA | biological_process |
| GO:0090080 | Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6076357433 | 0.7406534516 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1267446034 |
| GSE13712_SHEAR | Down | -0.3232564457 |
| GSE13712_STATIC | Up | 0.1758703847 |
| GSE19018 | Up | 0.1290900228 |
| GSE19899_A1 | Down | -0.2276896747 |
| GSE19899_A2 | Up | 0.3143600177 |
| PubMed_21979375_A1 | Down | -0.0473925567 |
| PubMed_21979375_A2 | Up | 0.0872357108 |
| GSE35957 | Up | 0.1918615861 |
| GSE36640 | Up | 0.2391725007 |
| GSE54402 | Down | -0.0204218079 |
| GSE9593 | Up | 0.0407112364 |
| GSE43922 | Up | 0.0176264881 |
| GSE24585 | Down | -0.0124454899 |
| GSE37065 | Down | -0.1762503013 |
| GSE28863_A1 | Down | -0.0820593845 |
| GSE28863_A2 | Up | 0.1217001767 |
| GSE28863_A3 | Up | 0.1401150899 |
| GSE28863_A4 | Up | 0.1769165694 |
| GSE48662 | Up | 0.0507089839 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
