HCSGD entry for SACS
1. General information
| Official gene symbol | SACS |
|---|---|
| Entrez ID | 26278 |
| Gene full name | spastic ataxia of Charlevoix-Saguenay (sacsin) |
| Other gene symbols | ARSACS DNAJC29 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006457 | Protein folding | NAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0030424 | Axon | TAS | cellular_component |
| GO:0030425 | Dendrite | TAS | cellular_component |
| GO:0030544 | Hsp70 protein binding | IPI | molecular_function |
| GO:0051087 | Chaperone binding | IDA | molecular_function |
| GO:0070628 | Proteasome binding | IPI | molecular_function |
| GO:0070852 | Cell body fiber | TAS | cellular_component |
| GO:0090084 | Negative regulation of inclusion body assembly | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8214784127 | 0.0172930474 | 0.9999902473 | 0.2574145845 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5539699426 |
| GSE13712_SHEAR | Up | 0.4626032122 |
| GSE13712_STATIC | Up | 0.1299349624 |
| GSE19018 | Down | -0.2429494323 |
| GSE19899_A1 | Down | -0.0610249647 |
| GSE19899_A2 | Down | -0.7140432435 |
| PubMed_21979375_A1 | Up | 0.0298506719 |
| PubMed_21979375_A2 | Down | -0.8150497710 |
| GSE35957 | Up | 0.1239661926 |
| GSE36640 | Down | -1.2320589210 |
| GSE54402 | Up | 0.3891002319 |
| GSE9593 | Down | -0.3156189026 |
| GSE43922 | Down | -0.1122582283 |
| GSE24585 | Down | -1.0678441676 |
| GSE37065 | Down | -0.1936482673 |
| GSE28863_A1 | Up | 0.2126086019 |
| GSE28863_A2 | Up | 0.1361783145 |
| GSE28863_A3 | Down | -0.2813968185 |
| GSE28863_A4 | Up | 0.1602154190 |
| GSE48662 | Down | -0.3100928917 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027667 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029563 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036435 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT042454 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
