HCSGD entry for FBXO4
1. General information
| Official gene symbol | FBXO4 |
|---|---|
| Entrez ID | 26272 |
| Gene full name | F-box protein 4 |
| Other gene symbols | FBX4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0000723 | Telomere maintenance | IMP | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | cellular_component |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0031398 | Positive regulation of protein ubiquitination | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9779809582 | 0.0191002621 | 0.9999902473 | 0.2707429570 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0510251759 |
| GSE13712_SHEAR | Down | -0.1200538024 |
| GSE13712_STATIC | Down | -0.0178855706 |
| GSE19018 | Down | -0.1042159443 |
| GSE19899_A1 | Down | -0.2243462388 |
| GSE19899_A2 | Down | -1.0162004050 |
| PubMed_21979375_A1 | Down | -0.3684370452 |
| PubMed_21979375_A2 | Down | -0.8285429756 |
| GSE35957 | Down | -0.0833249941 |
| GSE36640 | Down | -0.5745004291 |
| GSE54402 | Down | -0.3567988571 |
| GSE9593 | Down | -0.0259826648 |
| GSE43922 | Down | -0.7018090655 |
| GSE24585 | Up | 0.4516104256 |
| GSE37065 | Down | -0.1490349134 |
| GSE28863_A1 | Up | 0.0863235548 |
| GSE28863_A2 | Up | 0.1513468020 |
| GSE28863_A3 | Down | -0.5154942142 |
| GSE28863_A4 | Down | -0.1469895098 |
| GSE48662 | Down | -0.6581280825 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024311 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026787 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
