HCSGD entry for FBXO22
1. General information
| Official gene symbol | FBXO22 |
|---|---|
| Entrez ID | 26263 |
| Gene full name | F-box protein 22 |
| Other gene symbols | FBX22 FISTC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IEA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0006913 | Nucleocytoplasmic transport | IEA | biological_process |
| GO:0009267 | Cellular response to starvation | IEA | biological_process |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0032436 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0048742 | Regulation of skeletal muscle fiber development | IEA | biological_process |
| GO:2000060 | Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0248989552 | 0.9798433950 | 0.3720187181 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5811659523 |
| GSE13712_SHEAR | Up | 0.3873704408 |
| GSE13712_STATIC | Up | 0.4156557054 |
| GSE19018 | Up | 0.1564447475 |
| GSE19899_A1 | Up | 0.3627095495 |
| GSE19899_A2 | Up | 0.4025858723 |
| PubMed_21979375_A1 | Up | 0.2451654537 |
| PubMed_21979375_A2 | Up | 0.5439380561 |
| GSE35957 | Down | -0.0231062230 |
| GSE36640 | Up | 0.2395666574 |
| GSE54402 | Up | 0.1400251141 |
| GSE9593 | Down | -0.1708743013 |
| GSE43922 | Up | 0.2487371647 |
| GSE24585 | Up | 0.4546159967 |
| GSE37065 | Up | 0.1677433516 |
| GSE28863_A1 | Down | -0.1464102417 |
| GSE28863_A2 | Up | 0.0063449322 |
| GSE28863_A3 | Down | -0.4695702708 |
| GSE28863_A4 | Up | 0.2732377623 |
| GSE48662 | Down | -0.0454189015 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044372 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1 | MIMAT0000416 | MIRT046543 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26868148 | We find that Fbxo22 is highly expressed in senescent cells in a p53-dependent manner, and that SCF(Fbxo22) ubiquitylated p53 and formed a complex with a lysine demethylase, KDM4A |
| 26868148 | Ectopic expression of a catalytic mutant of KDM4A stabilizes p53 and enhances p53 interaction with PHF20 in the presence of Fbxo22 |
| 26868148 | Fbxo22(-/-) mice are almost half the size of Fbxo22(+/-) mice owing to the accumulation of p53 |
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