HCSGD entry for NKX2-8

1. General information

Official gene symbolNKX2-8
Entrez ID26257
Gene full nameNK2 homeobox 8
Other gene symbolsNKX2.8 NKX2H Nkx2-9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001889Liver developmentNASbiological_process
GO:0003690Double-stranded DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005634NucleusIEAcellular_component
GO:0006351Transcription, DNA-templatedIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007409AxonogenesisIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.50831273130.90257259220.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0446859254
GSE13712_SHEARUp0.0305128095
GSE13712_STATICUp0.1633504686
GSE19018Up0.2020773186
GSE19899_A1Down-0.0086335614
GSE19899_A2Up0.2536351812
PubMed_21979375_A1Down-0.1282021848
PubMed_21979375_A2Up0.2529909075
GSE35957Down-0.0936607379
GSE36640Down-0.0354500746
GSE54402Down-0.0303685023
GSE9593Up0.1739760139
GSE43922Up0.2442838680
GSE24585Down-0.1035819036
GSE37065Down-0.0530586910
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0201497703

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.