HCSGD entry for LDLRAP1

1. General information

Official gene symbolLDLRAP1
Entrez ID26119
Gene full namelow density lipoprotein receptor adaptor protein 1
Other gene symbolsARH ARH1 ARH2 FHCB1 FHCB2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001540Beta-amyloid bindingIPImolecular_function
GO:0001784Phosphotyrosine bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005546Phosphatidylinositol-4,5-bisphosphate bindingIDAmolecular_function
GO:0005769Early endosomeIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005883NeurofilamentISScellular_component
GO:0006810TransportNASbiological_process
GO:0006898Receptor-mediated endocytosisIDAbiological_process
GO:0008203Cholesterol metabolic processNASbiological_process
GO:0009898Cytoplasmic side of plasma membraneIDAcellular_component
GO:0009925Basal plasma membraneIDAcellular_component
GO:0009967Positive regulation of signal transductionIDAbiological_process
GO:0030121AP-1 adaptor complexIDAcellular_component
GO:0030122AP-2 adaptor complexIDAcellular_component
GO:0030159Receptor signaling complex scaffold activityIMPmolecular_function
GO:0030276Clathrin bindingIDAmolecular_function
GO:0030424AxonISScellular_component
GO:0031623Receptor internalizationIMPbiological_process
GO:0035591Signaling adaptor activityIDAmolecular_function
GO:0035612AP-2 adaptor complex bindingIDAmolecular_function
GO:0035615Clathrin adaptor activityIDAmolecular_function
GO:0042632Cholesterol homeostasisIMPbiological_process
GO:0042982Amyloid precursor protein metabolic processIMPbiological_process
GO:0043393Regulation of protein bindingIMPbiological_process
GO:0048260Positive regulation of receptor-mediated endocytosisIMPbiological_process
GO:0050750Low-density lipoprotein particle receptor bindingIPImolecular_function
GO:0055037Recycling endosomeIDAcellular_component
GO:0090003Regulation of establishment of protein localization to plasma membraneIMPbiological_process
GO:0090118Receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportIMPbiological_process
GO:0090205Positive regulation of cholesterol metabolic processICbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25999373880.42298609100.95313174091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1241693482
GSE13712_SHEARDown-0.1386754078
GSE13712_STATICDown-0.0184177914
GSE19018Up0.1856251070
GSE19899_A1Down-0.3497075101
GSE19899_A2Up0.2008024391
PubMed_21979375_A1Down-0.3446464315
PubMed_21979375_A2Up0.2051058499
GSE35957Up0.3683354696
GSE36640Up0.7316422864
GSE54402Down-0.1161725311
GSE9593Up0.4960474946
GSE43922Down-0.3241522889
GSE24585Up0.0896779638
GSE37065Down-0.1880365757
GSE28863_A1Down-0.0519425545
GSE28863_A2Up0.2058611835
GSE28863_A3Down-0.0607970833
GSE28863_A4Down-0.3521319237
GSE48662Up0.4919497283

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT004928MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT004928MicroarrayFunctional MTI (Weak)18668037
hsa-miR-9-5pMIMAT0000441MIRT021470MicroarrayFunctional MTI (Weak)17612493
hsa-miR-615-3pMIMAT0003283MIRT040455CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049748CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.