HCSGD entry for HERC4
1. General information
| Official gene symbol | HERC4 |
|---|---|
| Entrez ID | 26091 |
| Gene full name | HECT and RLD domain containing E3 ubiquitin protein ligase 4 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IBA | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0007283 | Spermatogenesis | IEA ISS | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3694643897 | 0.0329115041 | 0.9999902473 | 0.3423220861 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1695441894 |
| GSE13712_SHEAR | Up | 0.3345999455 |
| GSE13712_STATIC | Up | 0.1768162402 |
| GSE19018 | Up | 0.1907388823 |
| GSE19899_A1 | Down | -0.3060599745 |
| GSE19899_A2 | Down | -0.8550841219 |
| PubMed_21979375_A1 | Down | -0.3177670468 |
| PubMed_21979375_A2 | Down | -0.6725759812 |
| GSE35957 | Up | 0.2078492770 |
| GSE36640 | Up | 0.5286512776 |
| GSE54402 | Down | -0.4919462985 |
| GSE9593 | Up | 0.0497168376 |
| GSE43922 | Down | -0.3748247071 |
| GSE24585 | Down | -0.1822480242 |
| GSE37065 | Up | 0.2906054297 |
| GSE28863_A1 | Down | -0.4289038044 |
| GSE28863_A2 | Up | 0.6267398452 |
| GSE28863_A3 | Down | -1.1450230794 |
| GSE28863_A4 | Up | 0.3993338008 |
| GSE48662 | Down | -0.5127699331 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020643 | Reporter assay;Other | Non-Functional MTI | 20584899 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046760 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047890 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
