HCSGD entry for APPL1
1. General information
| Official gene symbol | APPL1 |
|---|---|
| Entrez ID | 26060 |
| Gene full name | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 |
| Other gene symbols | APPL DIP13alpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IC | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008283 | Cell proliferation | IDA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0010008 | Endosome membrane | IDA TAS | cellular_component |
| GO:0012506 | Vesicle membrane | IDA | cellular_component |
| GO:0016581 | NuRD complex | IDA | cellular_component |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042981 | Regulation of apoptotic process | TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043422 | Protein kinase B binding | IPI | molecular_function |
| GO:0046324 | Regulation of glucose import | IMP | biological_process |
| GO:0090003 | Regulation of establishment of protein localization to plasma membrane | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4201844801 | 0.0619221534 | 0.9999902473 | 0.4693234955 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6607797932 |
| GSE13712_SHEAR | Down | -0.0531695560 |
| GSE13712_STATIC | Down | -0.0086063172 |
| GSE19018 | Down | -0.5301062915 |
| GSE19899_A1 | Up | 0.1617757394 |
| GSE19899_A2 | Up | 0.2386570206 |
| PubMed_21979375_A1 | Up | 1.1127708474 |
| PubMed_21979375_A2 | Up | 0.9463522525 |
| GSE35957 | Down | -0.0463790349 |
| GSE36640 | Down | -1.1806287025 |
| GSE54402 | Down | -0.0537838574 |
| GSE9593 | Up | 0.1252960057 |
| GSE43922 | Up | 0.1177857327 |
| GSE24585 | Down | -0.2792495533 |
| GSE37065 | Down | -0.3869476779 |
| GSE28863_A1 | Up | 0.2519558236 |
| GSE28863_A2 | Up | 0.1244940340 |
| GSE28863_A3 | Down | -0.7420735803 |
| GSE28863_A4 | Down | -0.2093795322 |
| GSE48662 | Down | -0.0401865914 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019612 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024351 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026723 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027894 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028333 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030980 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037107 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042464 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042832 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051527 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051903 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26687460 | J Biomed Mater Res Part B: Appl Biomater, 2015 |
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