HCSGD entry for SIN3A

1. General information

Official gene symbolSIN3A
Entrez ID25942
Gene full nameSIN3 transcription regulator homolog A (yeast)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000776KinetochoreIEAcellular_component
GO:0000785ChromatinIEAcellular_component
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001103RNA polymerase II repressing transcription factor bindingIEAmolecular_function
GO:0001106RNA polymerase II transcription corepressor activityIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002218Activation of innate immune responseIMPbiological_process
GO:0002230Positive regulation of defense response to virus by hostIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003714Transcription corepressor activityRCAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIEAcellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0006476Protein deacetylationIMPbiological_process
GO:0007568AgingIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0010971Positive regulation of G2/M transition of mitotic cell cycleIEAbiological_process
GO:0016580Sin3 complexIDA NAScellular_component
GO:0017053Transcriptional repressor complexIEAcellular_component
GO:0031937Positive regulation of chromatin silencingIMPbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033558Protein deacetylase activityIMPmolecular_function
GO:0034613Cellular protein localizationIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043619Regulation of transcription from RNA polymerase II promoter in response to oxidative stressIEAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0051595Response to methylglyoxalIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:1900181Negative regulation of protein localization to nucleusIMPbiological_process
GO:1901675Negative regulation of histone H3-K27 acetylationIMPbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08285591350.91808933550.60702671121.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1114639637
GSE13712_SHEARDown-0.2189926851
GSE13712_STATICUp0.0148634545
GSE19018Up0.2979420557
GSE19899_A1Up0.0027826246
GSE19899_A2Up0.0388337437
PubMed_21979375_A1Up0.3063836483
PubMed_21979375_A2Up0.5072174263
GSE35957Down-0.1131954648
GSE36640Down-1.0018115761
GSE54402Up0.3180236560
GSE9593Up0.1869094320
GSE43922Up0.0097553001
GSE24585Up0.3741012322
GSE37065Up0.0999898669
GSE28863_A1Up0.8339184584
GSE28863_A2Up0.4813621229
GSE28863_A3Up0.0922363373
GSE28863_A4Down-0.0017514885
GSE48662Up0.0016828420

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020539ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1MIMAT0000416MIRT023524ProteomicsFunctional MTI (Weak)18668040
hsa-miR-455-3pMIMAT0004784MIRT037870CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038894CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040584CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049314CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.