HCSGD entry for WWTR1

1. General information

Official gene symbolWWTR1
Entrez ID25937
Gene full nameWW domain containing transcription regulator 1
Other gene symbolsTAZ
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIMPbiological_process
GO:0003713Transcription coactivator activityIDA IEA NASmolecular_function
GO:0003714Transcription corepressor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEA NAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006469Negative regulation of protein kinase activityIMPbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0017145Stem cell divisionIDAbiological_process
GO:0032835Glomerulus developmentIEAbiological_process
GO:0035329Hippo signalingIDA TASbiological_process
GO:0035414Negative regulation of catenin import into nucleusIMPbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA TASbiological_process
GO:0060271Cilium morphogenesisIEAbiological_process
GO:0060390Regulation of SMAD protein import into nucleusIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87540335470.01696396790.99999024730.2550020560

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0246630855
GSE13712_SHEARDown-0.6786764354
GSE13712_STATICDown-0.4876068298
GSE19018Down-1.2742959963
GSE19899_A1Down-0.2309877415
GSE19899_A2Down-1.0060287412
PubMed_21979375_A1Down-2.0495443873
PubMed_21979375_A2Down-0.8142190267
GSE35957Down-0.1000275415
GSE36640Up0.5850900913
GSE54402Down-0.0343729821
GSE9593Up0.2965777116
GSE43922Down-0.0002793060
GSE24585Up0.0214614168
GSE37065Up0.1326296598
GSE28863_A1Up0.1096420806
GSE28863_A2Up0.4832618725
GSE28863_A3Down-0.4278445478
GSE28863_A4Down-0.3070740234
GSE48662Up0.1875891850

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016501MicroarrayFunctional MTI (Weak)20304954
hsa-miR-335-5pMIMAT0000765MIRT018450MicroarrayFunctional MTI (Weak)18185580
hsa-miR-18a-5pMIMAT0000072MIRT050729CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.