HCSGD entry for HECTD1
1. General information
| Official gene symbol | HECTD1 |
|---|---|
| Entrez ID | 25831 |
| Gene full name | HECT domain containing E3 ubiquitin protein ligase 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IBA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0272941492 | 0.9536166901 | 0.3833560832 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1655349899 |
| GSE13712_SHEAR | Up | 0.3678762693 |
| GSE13712_STATIC | Up | 0.1630685944 |
| GSE19018 | Down | -0.0248748198 |
| GSE19899_A1 | Up | 0.0830021186 |
| GSE19899_A2 | Down | -0.3339186076 |
| PubMed_21979375_A1 | Down | -0.1212350235 |
| PubMed_21979375_A2 | Up | 0.4392885775 |
| GSE35957 | Up | 0.3806576105 |
| GSE36640 | Up | 0.1201976443 |
| GSE54402 | Up | 0.1999283185 |
| GSE9593 | Up | 0.1612837229 |
| GSE43922 | Down | -0.0506438649 |
| GSE24585 | Up | 0.1670695856 |
| GSE37065 | Down | -0.0144984125 |
| GSE28863_A1 | Up | 1.4360545077 |
| GSE28863_A2 | Up | 1.2525306127 |
| GSE28863_A3 | Down | -0.2207217007 |
| GSE28863_A4 | Up | 0.1177349529 |
| GSE48662 | Down | -0.0000593181 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003177 | immunoprecipitaion//Microarray//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018159 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028576 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030921 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046899 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
