HCSGD entry for BACE2
1. General information
| Official gene symbol | BACE2 |
|---|---|
| Entrez ID | 25825 |
| Gene full name | beta-site APP-cleaving enzyme 2 |
| Other gene symbols | AEPLC ALP56 ASP1 ASP21 BAE2 CEAP1 DRAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004190 | Aspartic-type endopeptidase activity | IDA | molecular_function |
| GO:0005768 | Endosome | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006508 | Proteolysis | NAS | biological_process |
| GO:0006509 | Membrane protein ectodomain proteolysis | IDA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0016486 | Peptide hormone processing | NAS | biological_process |
| GO:0042985 | Negative regulation of amyloid precursor protein biosynthetic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7519306295 | 0.0062506592 | 0.9999902473 | 0.1613735294 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0385879379 |
| GSE13712_SHEAR | Down | -0.3511165943 |
| GSE13712_STATIC | Down | -0.5282874418 |
| GSE19018 | Down | -1.5190482206 |
| GSE19899_A1 | Down | -0.6054820138 |
| GSE19899_A2 | Down | -0.6459320645 |
| PubMed_21979375_A1 | Down | -1.2664774213 |
| PubMed_21979375_A2 | Down | -0.4232191494 |
| GSE35957 | Up | 0.2843569828 |
| GSE36640 | Down | -2.2949159628 |
| GSE54402 | Down | -0.3974949698 |
| GSE9593 | Up | 0.5127685483 |
| GSE43922 | Down | -0.4163629086 |
| GSE24585 | Down | -0.3628064119 |
| GSE37065 | Down | -0.0904533333 |
| GSE28863_A1 | Up | 0.4821392679 |
| GSE28863_A2 | Up | 0.6843208235 |
| GSE28863_A3 | Up | 0.0068183192 |
| GSE28863_A4 | Down | -0.0580199804 |
| GSE48662 | Up | 0.8882916481 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042142 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
