HCSGD entry for NGEF

1. General information

Official gene symbolNGEF
Entrez ID25791
Gene full nameneuronal guanine nucleotide exchange factor
Other gene symbolsARHGEF27 EPHEXIN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0009987Cellular processIEAbiological_process
GO:0030426Growth coneIEAcellular_component
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityISSbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048013Ephrin receptor signaling pathwayISSbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0061002Negative regulation of dendritic spine morphogenesisISSbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09731431940.89053447820.65254961791.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1282087810
GSE13712_SHEARUp0.5278271953
GSE13712_STATICUp0.0553337988
GSE19018Down-0.0661434307
GSE19899_A1Up0.0670829271
GSE19899_A2Up0.0969932216
PubMed_21979375_A1Up0.2111553238
PubMed_21979375_A2Down-0.0265955272
GSE35957Down-0.1841241045
GSE36640Down-0.1035118817
GSE54402Up0.1948923849
GSE9593Down-0.0393792262
GSE43922Up0.0443823513
GSE24585Up0.3839255286
GSE37065Up0.1873664522
GSE28863_A1Down-0.1271813158
GSE28863_A2Up0.1978938454
GSE28863_A3Up0.3340166066
GSE28863_A4Up0.2269967132
GSE48662Up0.0112162424

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.