HCSGD entry for UBN2
1. General information
| Official gene symbol | UBN2 |
|---|---|
| Entrez ID | 254048 |
| Gene full name | ubinuclein 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2054116827 | 0.9355811709 | 0.8737299451 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0132032031 |
| GSE13712_SHEAR | Down | -0.1891695315 |
| GSE13712_STATIC | Down | -0.0413964433 |
| GSE19018 | Up | 0.1248878017 |
| GSE19899_A1 | Up | 0.1001270462 |
| GSE19899_A2 | Up | 0.0954126792 |
| PubMed_21979375_A1 | Up | 0.3232275517 |
| PubMed_21979375_A2 | Up | 0.2772914337 |
| GSE35957 | Down | -0.1572681166 |
| GSE36640 | Up | 0.2086219033 |
| GSE54402 | Up | 0.0123038006 |
| GSE9593 | Down | -0.1006211514 |
| GSE43922 | Up | 0.5055522948 |
| GSE24585 | Up | 0.0836196629 |
| GSE37065 | Up | 0.2293627904 |
| GSE28863_A1 | Up | 0.2104711649 |
| GSE28863_A2 | Down | -0.0291625430 |
| GSE28863_A3 | Up | 0.1409317911 |
| GSE28863_A4 | Down | -0.1339598718 |
| GSE48662 | Up | 0.2094023665 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027029 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031587 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047636 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048441 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051651 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19029251 | Using a sophisticated approach to search for remote orthologs conserved in multiple species through evolution, we identified the HIRA-associated proteins, UBN1 and UBN2, as candidate human orthologs of Hpc2p |
| 19029251 | We show that the Hpc2-related domain of UBN1, UBN2, and Hpc2p is an evolutionarily conserved HIRA/Hir-binding domain, which directly interacts with the N-terminal WD repeats of HIRA/Hir |
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