HCSGD entry for IFI6
1. General information
| Official gene symbol | IFI6 |
|---|---|
| Entrez ID | 2537 |
| Gene full name | interferon, alpha-inducible protein 6 |
| Other gene symbols | 6-16 FAM14C G1P3 IFI-6-16 IFI616 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001836 | Release of cytochrome c from mitochondria | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0051902 | Negative regulation of mitochondrial depolarization | IMP | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
| GO:2001240 | Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0009806390 | 0.0137444398 | 0.0852996700 | 0.2310136654 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.7658627221 |
| GSE13712_SHEAR | Up | 4.4152396553 |
| GSE13712_STATIC | Up | 3.4316269283 |
| GSE19018 | Up | 0.0480751000 |
| GSE19899_A1 | Down | -0.7730449780 |
| GSE19899_A2 | Down | -1.8793452808 |
| PubMed_21979375_A1 | Down | -2.4142256741 |
| PubMed_21979375_A2 | Down | -2.8715871283 |
| GSE35957 | Down | -3.2968847681 |
| GSE36640 | Up | 5.0981908965 |
| GSE54402 | Down | -0.9870980092 |
| GSE9593 | Up | 0.2760264810 |
| GSE43922 | Down | -0.6307546658 |
| GSE24585 | Up | 2.9348937228 |
| GSE37065 | Up | 1.2179420425 |
| GSE28863_A1 | Down | -0.1183222420 |
| GSE28863_A2 | Up | 0.0640478717 |
| GSE28863_A3 | Up | 0.0734583588 |
| GSE28863_A4 | Up | 0.1629155542 |
| GSE48662 | Up | 0.2638111844 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019676 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 14580871 | TGF-beta-treated prostate epithelial cells neither showed terminal growth arrest nor induction of important senescence-relevant genes, such as p16(INK4A), IFI-6-16, IGFBP-3 or Dkk-3 |
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