HCSGD entry for LCLAT1
1. General information
| Official gene symbol | LCLAT1 |
|---|---|
| Entrez ID | 253558 |
| Gene full name | lysocardiolipin acyltransferase 1 |
| Other gene symbols | 1AGPAT8 AGPAT8 ALCAT1 HSRG1849 LYCAT UNQ1849 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006654 | Phosphatidic acid biosynthetic process | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016024 | CDP-diacylglycerol biosynthetic process | IEA | biological_process |
| GO:0016746 | Transferase activity, transferring acyl groups | IEA | molecular_function |
| GO:0019432 | Triglyceride biosynthetic process | TAS | biological_process |
| GO:0035965 | Cardiolipin acyl-chain remodeling | TAS | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9961041260 | 0.0018184529 | 0.9999902473 | 0.0819580479 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4125481743 |
| GSE13712_SHEAR | Down | -0.4054988560 |
| GSE13712_STATIC | Down | -0.0480831584 |
| GSE19018 | Up | 0.0678013743 |
| GSE19899_A1 | Down | -1.4979184714 |
| GSE19899_A2 | Down | -1.1181604613 |
| PubMed_21979375_A1 | Down | -0.9370383210 |
| PubMed_21979375_A2 | Down | -0.6430729573 |
| GSE35957 | Up | 0.1782837066 |
| GSE36640 | Down | -0.5286996498 |
| GSE54402 | Down | -0.9783850537 |
| GSE9593 | Down | -0.0558873856 |
| GSE43922 | Down | -0.9230650538 |
| GSE24585 | Down | -0.5457868179 |
| GSE37065 | Down | -0.0537178451 |
| GSE28863_A1 | Down | -0.4621286012 |
| GSE28863_A2 | Down | -0.4137092302 |
| GSE28863_A3 | Down | -0.2586875703 |
| GSE28863_A4 | Down | -0.1193447539 |
| GSE48662 | Up | 0.0972165256 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT005252 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023154 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025101 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028546 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
