HCSGD entry for FUS
1. General information
| Official gene symbol | FUS |
|---|---|
| Entrez ID | 2521 |
| Gene full name | fused in sarcoma |
| Other gene symbols | ALS6 ETM4 FUS1 HNRNPP2 POMP75 TLS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6755017970 | 0.0130832111 | 0.9999902473 | 0.2254995422 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3955672386 |
| GSE13712_SHEAR | Down | -0.0786062269 |
| GSE13712_STATIC | Down | -0.2359550453 |
| GSE19018 | Down | -0.6838008310 |
| GSE19899_A1 | Down | -0.3417502178 |
| GSE19899_A2 | Down | -0.6081313773 |
| PubMed_21979375_A1 | Down | -0.0319336031 |
| PubMed_21979375_A2 | Down | -1.9357996739 |
| GSE35957 | Down | -0.5031816585 |
| GSE36640 | Down | -0.8525417656 |
| GSE54402 | Down | -0.0405815699 |
| GSE9593 | Down | -0.5331492789 |
| GSE43922 | Down | -0.0630257783 |
| GSE24585 | Down | -0.1202825285 |
| GSE37065 | Down | -0.1018991712 |
| GSE28863_A1 | Up | 0.8804387744 |
| GSE28863_A2 | Up | 0.7442388455 |
| GSE28863_A3 | Down | -0.0545997875 |
| GSE28863_A4 | Up | 0.4138736863 |
| GSE48662 | Down | -0.4747052268 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-197-3p | MIMAT0000227 | MIRT004196 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-664a-3p | MIMAT0005949 | MIRT035826 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036115 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040469 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043384 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046086 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046900 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047277 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047505 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052707 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26731744 | Contrary to LHT's prediction, women who had fewer children exhibited shorter TLs than those who had more children (p = 0 |
| 24021055 | RESULTS: Individuals with BD had shorter TLs but higher CMV IgG levels than controls (both p < 0 |
| 23971624 | CONCLUSIONS: TLs in memory CD4+ T cells in otherwise healthy adults are heterogeneous and follow distinct virus-specific kinetics |
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