HCSGD entry for NR5A2

1. General information

Official gene symbolNR5A2
Entrez ID2494
Gene full namenuclear receptor subfamily 5, group A, member 2
Other gene symbolsB1F B1F2 CPF FTF FTZ-F1 FTZ-F1beta LRH-1 LRH1 hB1F-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0008206Bile acid metabolic processIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009790Embryo developmentTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042592Homeostatic processNASbiological_process
GO:0042632Cholesterol homeostasisIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045070Positive regulation of viral genome replicationIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA TASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28692575890.85170961970.98653721931.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1178923275
GSE13712_SHEARUp0.3521267797
GSE13712_STATICDown-0.1402076886
GSE19018Down-0.1267201682
GSE19899_A1Down-0.0483678622
GSE19899_A2Down-0.1264344297
PubMed_21979375_A1Up0.1191566457
PubMed_21979375_A2Up0.0511859446
GSE35957Up0.2881406796
GSE36640Up0.2444986454
GSE54402Down-0.1820977451
GSE9593Up0.0865769865
GSE43922Up0.0170127604
GSE24585Up0.7762016382
GSE37065Down-0.0306915599
GSE28863_A1Down-0.0217390373
GSE28863_A2Down-0.0137681978
GSE28863_A3Up0.1495212352
GSE28863_A4Down-0.1164483039
GSE48662Up0.2748544376

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023720MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24488586The transcription factors predicted to regulate these changes, Nf-kappaB, Myb, Nkx2-1, Nr5a2, and Ep300, are known to regulate inflammation, differentiation, lipid metabolism, and chromatin remodeling, all of which have previously been implicated in aging
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