HCSGD entry for ALOX15

1. General information

Official gene symbolALOX15
Entrez ID246
Gene full namearachidonate 15-lipoxygenase
Other gene symbols15-LOX-1 15LOX-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationISSbiological_process
GO:0002820Negative regulation of adaptive immune responseIEA ISSbiological_process
GO:0004052Arachidonate 12-lipoxygenase activityIDA IEAmolecular_function
GO:0005506Iron ion bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005811Lipid particleIDAcellular_component
GO:0005829CytosolIDA IEA ISS TAScellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0006646Phosphatidylethanolamine biosynthetic processIEA ISSbiological_process
GO:0006691Leukotriene metabolic processTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0010811Positive regulation of cell-substrate adhesionIDAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016702Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenIEAmolecular_function
GO:0019369Arachidonic acid metabolic processIDA IEA NAS TASbiological_process
GO:0019372Lipoxygenase pathwayIDA IEA TASbiological_process
GO:0030282Bone mineralizationIEA ISSbiological_process
GO:0030838Positive regulation of actin filament polymerizationIEA ISSbiological_process
GO:0034976Response to endoplasmic reticulum stressIEA ISSbiological_process
GO:0035358Regulation of peroxisome proliferator activated receptor signaling pathwayIEA ISSbiological_process
GO:0035963Cellular response to interleukin-13IMPbiological_process
GO:0042060Wound healingIEA ISSbiological_process
GO:0043277Apoptotic cell clearanceIEA ISSbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0050473Arachidonate 15-lipoxygenase activityIDA IEA NASmolecular_function
GO:0051122Hepoxilin biosynthetic processISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0097260Eoxin A4 synthase activityTASmolecular_function
GO:1901074Regulation of engulfment of apoptotic cellIEA ISSbiological_process
GO:2001303Lipoxin A4 biosynthetic processIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87529597280.37081711180.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0336460513
GSE13712_SHEARUp0.1106271083
GSE13712_STATICDown-0.1493122102
GSE19018Up0.0004470227
GSE19899_A1Up0.0424239523
GSE19899_A2Down-0.0859964514
PubMed_21979375_A1Down-0.1343015531
PubMed_21979375_A2Up0.0582352378
GSE35957Down-0.1823523864
GSE36640Up0.0438107318
GSE54402Up0.0080443588
GSE9593Down-0.2763835997
GSE43922Up0.0231708843
GSE24585Up0.3390539487
GSE37065Down-0.1809267573
GSE28863_A1Down-0.0997321245
GSE28863_A2Down-0.3412525916
GSE28863_A3Up0.2269250858
GSE28863_A4Up0.0684540199
GSE48662Down-0.1889078415

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACIDDB08492 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.