HCSGD entry for ALK
1. General information
| Official gene symbol | ALK |
|---|---|
| Entrez ID | 238 |
| Gene full name | anaplastic lymphoma receptor tyrosine kinase |
| Other gene symbols | CD246 NBLST3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | IEA TAS | biological_process |
| GO:0004704 | NF-kappaB-inducing kinase activity | TAS | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IDA | molecular_function |
| GO:0004714 | Transmembrane receptor protein tyrosine kinase activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005887 | Integral component of plasma membrane | IDA TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0016310 | Phosphorylation | IDA TAS | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA TAS | biological_process |
| GO:0023014 | Signal transduction by phosphorylation | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0038061 | NIK/NF-kappaB signaling | TAS | biological_process |
| GO:0042981 | Regulation of apoptotic process | TAS | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0046777 | Protein autophosphorylation | IDA TAS | biological_process |
| GO:0048666 | Neuron development | IEA TAS | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1835971506 | 0.9546139622 | 0.8378204159 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1076857081 |
| GSE13712_SHEAR | Up | 0.1233165651 |
| GSE13712_STATIC | Up | 0.0867107875 |
| GSE19018 | Down | -0.0103780831 |
| GSE19899_A1 | Down | -0.1443441423 |
| GSE19899_A2 | Up | 0.1693516409 |
| PubMed_21979375_A1 | Down | -0.4091500484 |
| PubMed_21979375_A2 | Up | 0.0725040284 |
| GSE35957 | Up | 0.0806310690 |
| GSE36640 | Down | -0.0122168981 |
| GSE54402 | Up | 0.4830796828 |
| GSE9593 | Up | 0.0022993657 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.4164046235 |
| GSE28863_A2 | Up | 0.7169948795 |
| GSE28863_A3 | Up | 0.0436269890 |
| GSE28863_A4 | Up | 0.0548665106 |
| GSE48662 | Up | 0.0798692743 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine triphosphate | DB00171 | NUTR00017 | EXPT00007 |
| Crizotinib | DB08865 | - |
| Ceritinib | DB09063 | - |
| Alectinib | DB11363 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-132-3p | MIMAT0000426 | MIRT021811 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
