HCSGD entry for POLA2
1. General information
| Official gene symbol | POLA2 |
|---|---|
| Entrez ID | 23649 |
| Gene full name | polymerase (DNA directed), alpha 2, accessory subunit |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000060 | Protein import into nucleus, translocation | IEA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000722 | Telomere maintenance via recombination | TAS | biological_process |
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005658 | Alpha DNA polymerase:primase complex | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA NAS | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0032201 | Telomere maintenance via semi-conservative replication | TAS | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8828726758 | 0.0472075149 | 0.9999902473 | 0.4079281024 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0788605695 |
| GSE13712_SHEAR | Down | -0.1958557719 |
| GSE13712_STATIC | Up | 0.0714017505 |
| GSE19018 | Up | 0.1304593732 |
| GSE19899_A1 | Down | -0.1329934961 |
| GSE19899_A2 | Down | -0.4564458935 |
| PubMed_21979375_A1 | Down | -0.0791583812 |
| PubMed_21979375_A2 | Down | -0.6550738751 |
| GSE35957 | Down | -0.3041204488 |
| GSE36640 | Down | -0.7191537660 |
| GSE54402 | Up | 0.0567948348 |
| GSE9593 | Down | -0.3370448604 |
| GSE43922 | Down | -0.1602562391 |
| GSE24585 | Down | -0.0060682650 |
| GSE37065 | Up | 0.0820759287 |
| GSE28863_A1 | Down | -0.0135239381 |
| GSE28863_A2 | Up | 0.8105223089 |
| GSE28863_A3 | Down | -0.1709183280 |
| GSE28863_A4 | Down | -0.1007001113 |
| GSE48662 | Down | -0.8270529099 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001348 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024956 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026640 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
