HCSGD entry for PATZ1
1. General information
| Official gene symbol | PATZ1 |
|---|---|
| Entrez ID | 23598 |
| Gene full name | POZ (BTB) and AT hook containing zinc finger 1 |
| Other gene symbols | MAZR PATZ RIAZ ZBTB19 ZNF278 ZSG dJ400N23 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0030217 | T cell differentiation | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9707665666 | 0.0982801565 | 0.9999902473 | 0.5991147290 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0173465345 |
| GSE13712_SHEAR | Down | -0.2065683086 |
| GSE13712_STATIC | Down | -0.2610614292 |
| GSE19018 | Down | -0.0696353332 |
| GSE19899_A1 | Down | -0.0630618421 |
| GSE19899_A2 | Down | -0.4425774771 |
| PubMed_21979375_A1 | Down | -0.4495985848 |
| PubMed_21979375_A2 | Down | -0.2965410423 |
| GSE35957 | Down | -0.3884497611 |
| GSE36640 | Down | -0.5858246139 |
| GSE54402 | Down | -0.1586883222 |
| GSE9593 | Down | -0.1962168847 |
| GSE43922 | Down | -0.3843095542 |
| GSE24585 | Down | -0.1170432907 |
| GSE37065 | Up | 0.0102017859 |
| GSE28863_A1 | Up | 0.1566218787 |
| GSE28863_A2 | Up | 0.1421182043 |
| GSE28863_A3 | Up | 0.0179664969 |
| GSE28863_A4 | Up | 0.0269602876 |
| GSE48662 | Up | 0.3053806936 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-100-5p | MIMAT0000098 | MIRT048585 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25515777 | We previously reported that Patz1 is required for maintenance of ES cell identity |
| 25515777 | Here we report that Patz1 plays an inhibitory role in OKSM-induced reprogramming process since more iPS colonies can be induced from Patz1(+/-) MEFs than wild type MEFs; while the addition of Patz1 significantly repressed reprogramming efficiency |
| 25515777 | Patz1(+/-) MEFs can surpass the senescence barrier of Ink4a/Arf locus, thus enhancing iPS colonies formation |
| 25515777 | Moreover, Patz1(+/-) MEFs displayed higher levels of acetylated histone H3, H3K4me2, H3K4me3, H3K36me3 and lower levels of histone H3K9me3 and HP1alpha, indicating that heterozygous knockout of Patz1 results in a globally open chromatin which is more accessible for transcriptional activation |
| 25515777 | However, Patz1(-/-) MEFs gave the lowest reprogramming efficiency which may result from cell senescence trigged by up-regulated Ink4a/Arf locus |
| 22052190 | POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway |
| 22052190 | Using complementary DNA microarray technology, we found that the level of POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) is downregulated during endothelial cell (EC) senescence |
| 22052190 | PATZ1 may have an important role as a transcriptional repressor in chromatin remodeling and transcription regulation; however, the role of PATZ1 in EC senescence and vascular aging remains unidentified |
| 22052190 | Knockdown of PATZ1 in young cells accelerated premature EC senescence, which was confirmed by growth arrest, increased p53 protein level and senescence-associated beta-galactosidase (SA-beta-gal) activity, and repression of EC tube formation |
| 22052190 | In contrast, overexpression of PATZ1 in senescent cells reversed senescent phenotypes |
| 22052190 | Cellular senescence induced by PATZ1 knockdown in young cells was rescued by knockdown of p53, but not by knockdown of p16(INK4a) |
| 22052190 | PATZ1 knockdown increased ROS levels, and pretreatment with N-acetylcysteine abolished EC senescence induced by PATZ1 knockdown |
| 22052190 | Notably, PATZ1 immunoreactivity was lower in ECs of atherosclerotic tissues than those of normal arteries in LDLR(-/-) mice, and immunoreactivity also decreased in ECs of old human arteries |
| 22052190 | These results suggest that PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging |
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