HCSGD entry for LEMD3
1. General information
| Official gene symbol | LEMD3 |
|---|---|
| Entrez ID | 23592 |
| Gene full name | LEM domain containing 3 |
| Other gene symbols | MAN1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005637 | Nuclear inner membrane | IDA | cellular_component |
| GO:0005639 | Integral component of nuclear inner membrane | IEA | cellular_component |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0030514 | Negative regulation of BMP signaling pathway | IDA | biological_process |
| GO:0032926 | Negative regulation of activin receptor signaling pathway | IDA | biological_process |
| GO:0035914 | Skeletal muscle cell differentiation | IEA | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1050371149 | 0.7846468979 | 0.6733273015 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1578982732 |
| GSE13712_SHEAR | Down | -0.2100399306 |
| GSE13712_STATIC | Up | 0.0730174459 |
| GSE19018 | Down | -0.6810685792 |
| GSE19899_A1 | Up | 0.4019762717 |
| GSE19899_A2 | Up | 0.0863850186 |
| PubMed_21979375_A1 | Up | 0.8450370504 |
| PubMed_21979375_A2 | Up | 0.3480307330 |
| GSE35957 | Up | 0.1228088273 |
| GSE36640 | Up | 0.3970354957 |
| GSE54402 | Up | 0.1338376373 |
| GSE9593 | Down | -0.0905076391 |
| GSE43922 | Up | 0.2675324827 |
| GSE24585 | Up | 0.0009286074 |
| GSE37065 | Up | 0.0216025226 |
| GSE28863_A1 | Up | 0.3618486007 |
| GSE28863_A2 | Up | 0.4176399028 |
| GSE28863_A3 | Down | -0.1111544488 |
| GSE28863_A4 | Up | 0.1222119903 |
| GSE48662 | Down | -0.1463186726 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018252 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020835 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023852 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT030644 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047401 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047520 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
