HCSGD entry for DDX58

1. General information

Official gene symbolDDX58
Entrez ID23586
Gene full nameDEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Other gene symbolsRIG-I RIGI RLR-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002230Positive regulation of defense response to virus by hostIMPbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003725Double-stranded RNA bindingIDA IEA IMP TASmolecular_function
GO:0003727Single-stranded RNA bindingIEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005923Tight junctionIDAcellular_component
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0009597Detection of virusIDAbiological_process
GO:0009615Response to virusIEA TASbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0030334Regulation of cell migrationIDAbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0032727Positive regulation of interferon-alpha productionIDA IMPbiological_process
GO:0032728Positive regulation of interferon-beta productionIDA IEA IMPbiological_process
GO:0034344Regulation of type III interferon productionTASbiological_process
GO:0039528Cytoplasmic pattern recognition receptor signaling pathway in response to virusTASbiological_process
GO:0039529RIG-I signaling pathwayIMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042993Positive regulation of transcription factor import into nucleusIDAbiological_process
GO:0043330Response to exogenous dsRNAIEAbiological_process
GO:0045087Innate immune responseIEA IMP TASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00558679000.27081145090.19685394910.9954546077

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3255643614
GSE13712_SHEARUp2.0465010326
GSE13712_STATICUp1.2429944632
GSE19018Down-0.2145575354
GSE19899_A1Down-0.0351431732
GSE19899_A2Down-0.1983969731
PubMed_21979375_A1Down-0.2355178247
PubMed_21979375_A2Down-0.0463262633
GSE35957Down-1.6693107932
GSE36640Up1.6020685616
GSE54402Down-0.1257537821
GSE9593Up0.4245752267
GSE43922Up0.0310910100
GSE24585Up1.5437331591
GSE37065Up1.4197538729
GSE28863_A1Down-0.4580515988
GSE28863_A2Up1.2220359680
GSE28863_A3Down-0.8335508884
GSE28863_A4Up0.0864397847
GSE48662Up0.1386341272

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21336305We demonstrate that retinoic-acid-inducible gene-I (RIG-I) is induced through the ataxia telangiectasia mutated-interferon regulatory factor 1 (ATM-IRF1) axis in senescent cells and that RIG-I signalling mediates the expression of two important mediators of inflammation, interleukin-6 (IL-6) and IL-8
21336305We show here that the intracellular, but not the secreted, form of klotho interacts with RIG-I and that this interaction inhibits RIG-I-induced expression of IL-6 and IL-8 both in vitro and in vivo
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