HCSGD entry for DDAH1
1. General information
| Official gene symbol | DDAH1 |
|---|---|
| Entrez ID | 23576 |
| Gene full name | dimethylarginine dimethylaminohydrolase 1 |
| Other gene symbols | DDAH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000052 | Citrulline metabolic process | IDA | biological_process |
| GO:0003073 | Regulation of systemic arterial blood pressure | ISS | biological_process |
| GO:0003824 | Catalytic activity | TAS | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006527 | Arginine catabolic process | TAS | biological_process |
| GO:0007263 | Nitric oxide mediated signal transduction | TAS | biological_process |
| GO:0016403 | Dimethylargininase activity | IDA | molecular_function |
| GO:0016597 | Amino acid binding | IEA | molecular_function |
| GO:0016813 | Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines | IEA | molecular_function |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | ISS | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8267416132 | 0.0007029786 | 0.9999902473 | 0.0501388140 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9344735248 |
| GSE13712_SHEAR | Up | 0.4549926578 |
| GSE13712_STATIC | Down | -0.1614668987 |
| GSE19018 | Down | -0.7246318446 |
| GSE19899_A1 | Down | -0.8477445628 |
| GSE19899_A2 | Down | -1.1329181107 |
| PubMed_21979375_A1 | Down | -2.0268646582 |
| PubMed_21979375_A2 | Down | -1.9930716577 |
| GSE35957 | Up | 1.6138673774 |
| GSE36640 | Up | 0.6731408932 |
| GSE54402 | Down | -1.4069968126 |
| GSE9593 | Up | 0.8528962843 |
| GSE43922 | Down | -0.7142504207 |
| GSE24585 | Up | 0.0618515651 |
| GSE37065 | Down | -0.6400637287 |
| GSE28863_A1 | Down | -0.6523868508 |
| GSE28863_A2 | Down | -0.4153290687 |
| GSE28863_A3 | Down | -0.4895701890 |
| GSE28863_A4 | Down | -0.3344465954 |
| GSE48662 | Down | -0.3311889773 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003179 | immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR | Functional MTI | 19826008 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023452 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025359 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030838 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040900 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046866 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048463 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049248 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050653 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23466301 | In particular, the expression levels of 9 genes, HSP90B1, EID1, ATP2B4, DDAH1, PRNP, RAB1A, PGS5, TM4SF1 and SSR3, gradually increased during senescence |
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