HCSGD entry for DDAH2
1. General information
| Official gene symbol | DDAH2 |
|---|---|
| Entrez ID | 23564 |
| Gene full name | dimethylarginine dimethylaminohydrolase 2 |
| Other gene symbols | DDAH DDAHII G6a NG30 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000052 | Citrulline metabolic process | IDA | biological_process |
| GO:0003824 | Catalytic activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006525 | Arginine metabolic process | IEA | biological_process |
| GO:0006527 | Arginine catabolic process | TAS | biological_process |
| GO:0006809 | Nitric oxide biosynthetic process | TAS | biological_process |
| GO:0007263 | Nitric oxide mediated signal transduction | TAS | biological_process |
| GO:0016403 | Dimethylargininase activity | IDA | molecular_function |
| GO:0016597 | Amino acid binding | IEA | molecular_function |
| GO:0016813 | Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines | IEA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9837205919 | 0.0033731355 | 0.9999902473 | 0.1178163130 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1984505489 |
| GSE13712_SHEAR | Down | -0.2089640051 |
| GSE13712_STATIC | Down | -0.4296817482 |
| GSE19018 | Down | -0.4191628754 |
| GSE19899_A1 | Down | -1.2494885818 |
| GSE19899_A2 | Down | -1.7504479585 |
| PubMed_21979375_A1 | Down | -1.0055429912 |
| PubMed_21979375_A2 | Down | -2.8785049182 |
| GSE35957 | Down | -0.0782679159 |
| GSE36640 | Down | -0.2392701464 |
| GSE54402 | Down | -0.4454574202 |
| GSE9593 | Down | -0.2913909655 |
| GSE43922 | Down | -1.1065343991 |
| GSE24585 | Up | 0.2763695011 |
| GSE37065 | Down | -0.1629898890 |
| GSE28863_A1 | Down | -0.1472272555 |
| GSE28863_A2 | Down | -0.2651526594 |
| GSE28863_A3 | Down | -0.3101470671 |
| GSE28863_A4 | Down | -0.0104161468 |
| GSE48662 | Up | 0.2135834960 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025565 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20132235 | The beneficial effects of BTM-0512 on high glucose-induced senescence were blocked by splimtomicin, the specific inhibitor of SIRT1, or by silencing DDAH2 expression |
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